| Literature DB >> 23707077 |
Yi Yongjun1, Huang Shuyun, Chen Lei, Chen Xiangrong, Yang Zhilin, Ke Yiquan.
Abstract
Microglia, the immune cells of the brain, often present in large numbers in gliomas, where they promote tumor growth and invasiveness. This study found that atorvastatin reduced the pro-tumorigenic effects of microglia on glioma migration and invasion by reducing the microglial expression of membrane type 1 metalloproteinase (MT1-MMP). The results suggest that down-regulation of MT1-MMP is controlled by a p38 MAPK pathway in microglia. Taken together, the results support further research on atorvastatin as a candidate for glioma therapy by targeting microglia.Entities:
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Year: 2013 PMID： 23707077 DOI： 10.1016/j.jneuroim.2013.04.020
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478