Literature DB >> 26374633

Repurposing some older drugs that cross the blood-brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma.

Dayle Rundle-Thiele1, Richard Head2, Leah Cosgrove3, Jennifer H Martin4.   

Abstract

Glioblastoma is a brain neoplasm with limited 5-year survival rates. Developments of new treatment regimens that improve patient survival in patients with glioblastoma are needed. It is likely that a number of existing drugs used in other conditions have potential anticancer effects that offer significant survival benefit to glioblastoma patients. Identification of such drugs could provide a novel treatment paradigm.
© 2015 The British Pharmacological Society.

Entities:  

Keywords:  antidepressants; antiepileptic drugs; antihypertensive; beta-blockers; glioblastoma; statins

Mesh：

Substances：

Year:  2015        PMID： 26374633      PMCID： PMC4833171          DOI： 10.1111/bcp.12785

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  78 in total

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2.  Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells.

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Journal:  Cell       Date:  2012-05-24       Impact factor: 41.582

3.  Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

Authors:  M Esteller; J Garcia-Foncillas; E Andion; S N Goodman; O F Hidalgo; V Vanaclocha; S B Baylin; J G Herman
Journal:  N Engl J Med       Date:  2000-11-09       Impact factor: 91.245

Review 4.  Statins and neuroprotection: a prescription to move the field forward.

Authors:  W Gibson Wood; Gunter P Eckert; Urule Igbavboa; Walter E Müller
Journal:  Ann N Y Acad Sci       Date:  2010-06       Impact factor: 5.691

5.  MGMT gene silencing and benefit from temozolomide in glioblastoma.

Authors:  Monika E Hegi; Annie-Claire Diserens; Thierry Gorlia; Marie-France Hamou; Nicolas de Tribolet; Michael Weller; Johan M Kros; Johannes A Hainfellner; Warren Mason; Luigi Mariani; Jacoline E C Bromberg; Peter Hau; René O Mirimanoff; J Gregory Cairncross; Robert C Janzer; Roger Stupp
Journal:  N Engl J Med       Date:  2005-03-10       Impact factor: 91.245

Review 6.  Hypoxia helps glioma to fight therapy.

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7.  Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression.

Authors:  Yi Yongjun; Huang Shuyun; Chen Lei; Chen Xiangrong; Yang Zhilin; Ke Yiquan
Journal:  J Neuroimmunol       Date:  2013-05-21       Impact factor: 3.478

8.  The activity of antiepileptic drugs as histone deacetylase inhibitors.

Authors:  Sara Eyal; Boris Yagen; Eyal Sobol; Yoram Altschuler; Miriam Shmuel; Meir Bialer
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9.  Correlation of enzyme-inducing anticonvulsant use with outcome of patients with glioblastoma.

Authors:  Kurt A Jaeckle; Karla Ballman; Alfred Furth; Jan C Buckner
Journal:  Neurology       Date:  2009-10-13       Impact factor: 9.910

10.  Drugs affecting the renin-angiotensin system and survival from cancer: a population based study of breast, colorectal and prostate cancer patient cohorts.

Authors:  Chris R Cardwell; Úna C Mc Menamin; Blánaid M Hicks; Carmel Hughes; Marie M Cantwell; Liam J Murray
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  21 in total

1.  Blood-brain barrier crossing and breakthroughs in glioblastoma therapy.

Authors:  P Sminia; B A Westerman
Journal:  Br J Clin Pharmacol       Date:  2016-02-08       Impact factor: 4.335

2.  A novel computational approach for drug repurposing using systems biology.

Authors:  Azam Peyvandipour; Nafiseh Saberian; Adib Shafi; Michele Donato; Sorin Draghici
Journal:  Bioinformatics       Date:  2018-08-15       Impact factor: 6.937

3.  The interplay among psychological distress, the immune system, and brain tumor patient outcomes.

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Review 4.  Translational gap in ongoing clinical trials for glioma.

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5.  The Impact of the Antipsychotic Medication Chlorpromazine on Cytotoxicity through Ca2+ Signaling Pathway in Glial Cell Models.

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6.  Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma.

Authors:  Stefania Maraka; Morris D Groves; Aaron G Mammoser; Isaac Melguizo-Gavilanes; Charles A Conrad; Ivo W Tremont-Lukats; Monica E Loghin; Barbara J O'Brien; Vinay K Puduvalli; Erik P Sulman; Kenneth R Hess; Kenneth D Aldape; Mark R Gilbert; John F de Groot; W K Alfred Yung; Marta Penas-Prado
Journal:  Cancer       Date:  2018-10-25       Impact factor: 6.860

7.  Does the choice of antiepileptic drug affect survival in glioblastoma patients?

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Journal:  J Neurooncol       Date:  2016-07-04       Impact factor: 4.130

Review 8.  Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma.

Authors:  R J Head; M F Fay; L Cosgrove; K Y C Fung; D Rundle-Thiele; J H Martin
Journal:  Cancer Biol Ther       Date:  2017-11-20       Impact factor: 4.742

9.  Antipsychotic drugs elicit cytotoxicity in glioblastoma multiforme in a calcium-dependent, non-D2 receptor-dependent, manner.

Authors:  Jillian S Weissenrieder; Jessie L Reed; George-Lucian Moldovan; Martin T Johnson; Mohamed Trebak; Jeffrey D Neighbors; Richard B Mailman; Raymond J Hohl
Journal:  Pharmacol Res Perspect       Date:  2021-05

Review 10.  Repurposing existing therapeutics, its importance in oncology drug development: Kinases as a potential target.

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Journal:  Br J Clin Pharmacol       Date:  2021-07-09       Impact factor: 3.716
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