Literature DB >> 23698292

Improving the effectiveness of artificial microRNA (amiR)-mediated resistance against Turnip mosaic virus by combining two amiRs or by targeting highly conserved viral genomic regions.

Guillaume Lafforgue1, Fernando Martínez, Qi-Wen Niu, Nam-Hai Chua, José-Antonio Daròs, Santiago F Elena.   

Abstract

A drawback of recent antiviral therapies based on the transgenic expression of artificial microRNAs (amiRs) is the ease with which viruses generate escape mutations. Here, we show two alternative strategies for improving the effectiveness of resistance in plants. First, we expressed two amiRs complementary to independent targets in the viral genome, and second, we designed amiRs complementary to highly conserved RNA motifs in the viral genome.

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Year:  2013        PMID： 23698292      PMCID： PMC3700214          DOI： 10.1128/JVI.00914-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  HIV develops indirect cross-resistance to combinatorial RNAi targeting two distinct and spatially distant sites.

Authors:  Priya S Shah; Nhung P Pham; David V Schaffer
Journal:  Mol Ther       Date:  2012-01-31       Impact factor: 11.454

2.  Effects of potyvirus effective population size in inoculated leaves on viral accumulation and the onset of symptoms.

Authors:  Mark P Zwart; José-Antonio Daròs; Santiago F Elena
Journal:  J Virol       Date:  2012-06-27       Impact factor: 5.103

3.  Luria-delbruck estimation of turnip mosaic virus mutation rate in vivo.

Authors:  Francisca de la Iglesia; Fernando Martínez; Julia Hillung; José M Cuevas; Philip J Gerrish; José-Antonio Daròs; Santiago F Elena
Journal:  J Virol       Date:  2012-01-11       Impact factor: 5.103

4.  RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription.

Authors:  Qing Ge; Michael T McManus; Tam Nguyen; Ching-Hung Shen; Phillip A Sharp; Herman N Eisen; Jianzhu Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-19       Impact factor: 11.205

5.  Resistance to Wheat streak mosaic virus generated by expression of an artificial polycistronic microRNA in wheat.

Authors:  Muhammad Fahim; Anthony A Millar; Craig C Wood; Philip J Larkin
Journal:  Plant Biotechnol J       Date:  2011-09-05       Impact factor: 9.803

6.  Human immunodeficiency virus type 1 escape from RNA interference.

Authors:  Daniel Boden; Oliver Pusch; Frederick Lee; Lynne Tucker; Bharat Ramratnam
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

7.  Alternative approaches for efficient inhibition of hepatitis C virus RNA replication by small interfering RNAs.

Authors:  Jan Krönke; Ralf Kittler; Frank Buchholz; Marc P Windisch; Thomas Pietschmann; Ralf Bartenschlager; Michael Frese
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

8.  Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference.

Authors:  Glen A Coburn; Bryan R Cullen
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

9.  Ultradeep sequencing analysis of population dynamics of virus escape mutants in RNAi-mediated resistant plants.

Authors:  Fernando Martínez; Guillaume Lafforgue; Marco J Morelli; Fernando González-Candelas; Nam-Hai Chua; José-Antonio Daròs; Santiago F Elena
Journal:  Mol Biol Evol       Date:  2012-05-15       Impact factor: 16.240

10.  Secondary structures in the capsid protein coding sequence and 3' nontranslated region involved in amplification of the tobacco etch virus genome.

Authors:  R Haldeman-Cahill; J A Daròs; J C Carrington
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103
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  8 in total

1.  Variability in the durability of CRISPR-Cas immunity.

Authors:  Hélène Chabas; Antoine Nicot; Sean Meaden; Edze R Westra; Denise M Tremblay; Léa Pradier; Sébastien Lion; Sylvain Moineau; Sylvain Gandon
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2019-05-13       Impact factor: 6.237

2.  Fast-forward generation of effective artificial small RNAs for enhanced antiviral defense in plants.

Authors:  Alberto Carbonell; James C Carrington; José-Antonio Daròs
Journal:  RNA Dis       Date:  2016-01-12

Review 3.  Biotechnological strategies and tools for Plum pox virus resistance: trans-, intra-, cis-genesis, and beyond.

Authors:  Vincenza Ilardi; Mario Tavazza
Journal:  Front Plant Sci       Date:  2015-06-08       Impact factor: 5.753

4.  Multi-targeting of viral RNAs with synthetic trans-acting small interfering RNAs enhances plant antiviral resistance.

Authors:  Alberto Carbonell; Purificación Lisón; José-Antonio Daròs
Journal:  Plant J       Date:  2019-09-16       Impact factor: 6.417

Review 5.  Resistance to Turnip Mosaic Virus in the Family Brassicaceae.

Authors:  Peter Palukaitis; Su Kim
Journal:  Plant Pathol J       Date:  2021-02-01       Impact factor: 1.795

6.  Targeting of genomic and negative-sense strands of viral RNA contributes to antiviral resistance mediated by artificial miRNAs and promotes the emergence of complex viral populations.

Authors:  Frida Mesel; Mingmin Zhao; Beatriz García; Carmen Simón-Mateo; Juan Antonio García
Journal:  Mol Plant Pathol       Date:  2022-08-21       Impact factor: 5.520

7.  Artificial microRNA-mediated resistance to cucumber green mottle mosaic virus in Nicotiana benthamiana.

Authors:  Chaoqiong Liang; Jianjun Hao; Jianqiang Li; Barbara Baker; Laixin Luo
Journal:  Planta       Date:  2019-08-06       Impact factor: 4.540

Review 8.  MicroRNA-Mediated Gene Silencing in Plant Defense and Viral Counter-Defense.

Authors:  Sheng-Rui Liu; Jing-Jing Zhou; Chun-Gen Hu; Chao-Ling Wei; Jin-Zhi Zhang
Journal:  Front Microbiol       Date:  2017-09-20       Impact factor: 5.640
  8 in total

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