Literature DB >> 25182649

Mechanisms of tigecycline resistance among Klebsiella pneumoniae clinical isolates.

Zi-Ke Sheng1, Fupin Hu1, Weixia Wang1, Qinglan Guo1, Zhijun Chen1, Xiaogang Xu1, Demei Zhu1, Minggui Wang2.   

Abstract

Of 26 tigecycline-nonsusceptible Klebsiella pneumoniae (TNSKP) clinical isolates, 25 had nonsynonymous mutations in ramR and/or acrR (23 in ramR and 10 in acrR). Eight TNSKP isolates possessed overexpression of ramA, acrB, rarA, and oqxB simultaneously, while 8 and 1 TNSKP strains had upregulation of ramA and acrB and of rarA and oqxB, respectively. Thus, resistance mechanisms of 9 TNSKP isolates cannot be explained by the present pathways. This study underscores the role of RamA in TNSKP and suggests the presence of novel tigecycline resistance mechanisms.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25182649      PMCID： PMC4249433          DOI： 10.1128/AAC.03808-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Characterization of RarA, a novel AraC family multidrug resistance regulator in Klebsiella pneumoniae.

Authors:  Mark Veleba; Paul G Higgins; Gerardo Gonzalez; Harald Seifert; Thamarai Schneiders
Journal:  Antimicrob Agents Chemother       Date:  2012-05-29       Impact factor: 5.191

2.  ramR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline.

Authors:  M Hentschke; M Wolters; I Sobottka; H Rohde; M Aepfelbacher
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

3.  Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae.

Authors:  Alexey Ruzin; Melissa A Visalli; David Keeney; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

4.  The in vitro evaluation of tigecycline tested against pathogens isolated in eight countries in the Asia-Western Pacific region (2008).

Authors:  David J Farrell; John D Turnidge; Jan Bell; Helio S Sader; Ronald N Jones
Journal:  J Infect       Date:  2010-03-31       Impact factor: 6.072

5.  Combined ramR mutation and presence of a Tn1721-associated tet(A) variant in a clinical isolate of Salmonella enterica serovar Hadar resistant to tigecycline.

Authors:  M Hentschke; M Christner; I Sobottka; M Aepfelbacher; H Rohde
Journal:  Antimicrob Agents Chemother       Date:  2009-12-22       Impact factor: 5.191

6.  ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium.

Authors:  Yousef M Abouzeed; Sylvie Baucheron; Axel Cloeckaert
Journal:  Antimicrob Agents Chemother       Date:  2008-04-28       Impact factor: 5.191

7.  MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli.

Authors:  David Keeney; Alexey Ruzin; Fionnuala McAleese; Ellen Murphy; Patricia A Bradford
Journal:  J Antimicrob Chemother       Date:  2007-10-29       Impact factor: 5.790

8.  Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance.

Authors:  Laura Villa; Claudia Feudi; Daniela Fortini; Aurora García-Fernández; Alessandra Carattoli
Journal:  Antimicrob Agents Chemother       Date:  2013-12-30       Impact factor: 5.191

9.  Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae.

Authors:  R Rosenblum; E Khan; G Gonzalez; R Hasan; T Schneiders
Journal:  Int J Antimicrob Agents       Date:  2011-04-22       Impact factor: 5.283

10.  Susceptibility of important Gram-negative pathogens to tigecycline and other antibiotics in Latin America between 2004 and 2010.

Authors:  Liliana Fernández-Canigia; Michael J Dowzicky
Journal:  Ann Clin Microbiol Antimicrob       Date:  2012-10-22       Impact factor: 3.944
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  27 in total

1.  Tigecycline resistance among Klebsiella pneumoniae isolated from febrile neutropenic patients.

Authors:  Sherein G Elgendy; Muhammad R Abdel Hameed; Mohamed A El-Mokhtar
Journal:  J Med Microbiol       Date:  2018-05-25       Impact factor: 2.472

Review 2.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

3.  Roles of ramR and tet(A) Mutations in Conferring Tigecycline Resistance in Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.

Authors:  Sheng-Kang Chiu; Li-Yueh Huang; Hsi Chen; Yu-Kuo Tsai; Ci-Hong Liou; Jung-Chung Lin; L Kristopher Siu; Feng-Yee Chang; Kuo-Ming Yeh
Journal:  Antimicrob Agents Chemother       Date:  2017-07-25       Impact factor: 5.191

Review 4.  Tetracycline Antibiotics and Resistance.

Authors:  Trudy H Grossman
Journal:  Cold Spring Harb Perspect Med       Date:  2016-04-01       Impact factor: 6.915

5.  Study on MICs of Tigecycline in Clinical Isolates of Carbapenem Resistant Enterobacteriaceae (CRE) at a Tertiary Care Centre in North India.

Authors:  Vineeta Khare; Prashant Gupta; Fareya Haider; Rehana Begum
Journal:  J Clin Diagn Res       Date:  2017-03-01

6.  Risk Factors, Outcomes, and Mechanisms of Tigecycline-Nonsusceptible Klebsiella pneumoniae Bacteremia.

Authors:  Chih-Han Juan; Yi-Wei Huang; Yi-Tsung Lin; Tsuey-Ching Yang; Fu-Der Wang
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

7.  First emergence of acrAB and oqxAB mediated tigecycline resistance in clinical isolates of Klebsiella pneumoniae pre-dating the use of tigecycline in a Chinese hospital.

Authors:  Xue Zhong; Hongtao Xu; Dongke Chen; Haijian Zhou; Xin Hu; Gang Cheng
Journal:  PLoS One       Date:  2014-12-12       Impact factor: 3.240

8.  Unusual carbapenem resistant but ceftriaxone and cefepime susceptible Klebsiella oxytoca isolated from a blood culture: Case report and whole-genome sequencing investigation.

Authors:  Shangxin Yang; Peera Hemarajata; Laura Shevy; Mario Maciariello; Karissa Culbreath; Karen Bush; Romney Humphries
Journal:  IDCases       Date:  2017-11-23

9.  Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin.

Authors:  Xi Jin; Qiong Chen; Fang Shen; Yan Jiang; Xueqing Wu; Xiaoting Hua; Ying Fu; Yunsong Yu
Journal:  Emerg Microbes Infect       Date:  2021-12       Impact factor: 7.163

10.  Tigecycline Resistant Klebsiella pneumoniae Isolated from Austrian River Water.

Authors:  Alexander Hladicz; Clemens Kittinger; Gernot Zarfel
Journal:  Int J Environ Res Public Health       Date:  2017-10-03       Impact factor: 3.390
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