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Literature DB >> 23681748

Chromosomal distribution of schizophrenia susceptibility loci.

Abstract

In order to find the chromosomal distribution of polymorphic loci associated with the schizophrenia risk, the present study was carried out. Meta-analysis studies with information of genetic polymorphisms and schizophrenia risk were identified and used for the present study. There were 39 loci associated with schizophrenia risk. Statistical analysis revealed that the schizophrenia susceptible loci distributed non-randomly on human chromosomes. Human chromosome segments 6p21.1-p22.3 (P < 0.001) bear significantly higher number of susceptible loci.

Entities: Disease Species

Mesh：

Year: 2013 PMID： 23681748 DOI： 10.1007/s12031-013-0028-2

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

11 in total

9. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

Authors:
Journal: Cytogenet Cell Genet Date: 1981

Chromosomal distribution of schizophrenia susceptibility loci.

1. The distribution of genes in the human genome.

2. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.

3. The highest gene concentrations in the human genome are in telomeric bands of metaphase chromosomes.

4. Identification of the gene-richest bands in human chromosomes.

5. Non-random distribution of breast cancer susceptibility loci on human chromosomes.

6. Fragile sites, cancer chromosome breakpoints, and oncogenes all cluster in light G bands.

7. The chromosome territory of human oncogenes.

8. A method for testing the nonrandomness of chromosomal breakpoints.

9. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

10. Telomeric location of retroviral oncogenes in humans.

1. Non-random distribution of gastric cancer susceptible loci on human chromosomes.

2. Distributions of susceptibility loci of Parkinson's disease and multiple sclerosis on human chromosomes.

3. Distributions of susceptibility loci to late onset Alzheimer's disease on human chromosomes.