Literature DB >> 23668594

Environmental study of azole-resistant Aspergillus fumigatus with TR34/L98H mutations in the cyp51A gene in Iran.

Hamid Badali1, Afsane Vaezi, Iman Haghani, Seyed A Yazdanparast, Mohammad T Hedayati, Bita Mousavi, Saham Ansari, Ferry Hagen, Jacques F Meis, Anuradha Chowdhary.   

Abstract

Azole resistance in Aspergillus is emerging in European and Asian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient management. We report the emergence of resistance to triazoles in environmental Aspergillus fumigatus isolates in Iran. The TR34/L98H mutation was the only resistance mechanism. Overall 3.3% of the A. fumigatus isolates from hospital surroundings in Sari and Tehran had the same TR34/L98H STRAf genotype and were related to some resistant clinical and environmental TR34/L98H isolates from the Netherlands and India. It is emphasised that routine resistance surveillance studies focusing on environmental and clinical samples are warranted to yield the true prevalence of azole resistance in A. fumigatus in Iran.
© 2013 Blackwell Verlag GmbH.

Entities:  

Keywords:  Aspergillus fumigatus; Iran; TR34/L98H; azole resistance; cyp51A; microsatellite typing

Mesh：

Substances：

Year:  2013        PMID： 23668594     DOI： 10.1111/myc.12089

Source DB:  PubMed          Journal:  Mycoses        ISSN： 0933-7407            Impact factor:   4.377


  30 in total

1.  Epidemiology and Molecular Characterizations of Azole Resistance in Clinical and Environmental Aspergillus fumigatus Isolates from China.

Authors:  Yong Chen; Zhongyi Lu; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Zhiyao Bao; Guangbin Qiu; Mingsheng Song; Qing Zhang; Lin Liu; Mandong Hu; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Changjian Zhang; Yansong Sun; Paul E Verweij; Liuyu Huang; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

Review 2.  Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.

Authors:  Jacques F Meis; Anuradha Chowdhary; Johanna L Rhodes; Matthew C Fisher; Paul E Verweij
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-12-05       Impact factor: 6.237

3.  Elevated Prevalence of Azole-Resistant Aspergillus fumigatus in Urban versus Rural Environments in the United Kingdom.

Authors:  Thomas R Sewell; Yuyi Zhang; Amelie P Brackin; Jennifer M G Shelton; Johanna Rhodes; Matthew C Fisher
Journal:  Antimicrob Agents Chemother       Date:  2019-08-23       Impact factor: 5.191

Review 4.  Aspergillus fumigatus and aspergillosis: From basics to clinics.

Authors:  A Arastehfar; A Carvalho; J Houbraken; L Lombardi; R Garcia-Rubio; J D Jenks; O Rivero-Menendez; R Aljohani; I D Jacobsen; J Berman; N Osherov; M T Hedayati; M Ilkit; D James-Armstrong; T Gabaldón; J Meletiadis; M Kostrzewa; W Pan; C Lass-Flörl; D S Perlin; M Hoenigl
Journal:  Stud Mycol       Date:  2021-05-10       Impact factor: 16.097

5.  Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.

Authors:  Musang Liu; Rong Zeng; Lili Zhang; Dongmei Li; Guixia Lv; Yongnian Shen; Hailin Zheng; Qiangqiang Zhang; Jingjun Zhao; Nan Zheng; Weida Liu
Journal:  Antimicrob Agents Chemother       Date:  2015-04-20       Impact factor: 5.191

6.  Simple, low-cost molecular assays for TR34/L98H mutations in the cyp51A gene for rapid detection of triazole-resistant Aspergillus fumigatus isolates.

Authors:  Suhail Ahmad; Ziauddin Khan; Ferry Hagen; Jacques F Meis
Journal:  J Clin Microbiol       Date:  2014-04-09       Impact factor: 5.948

7.  Elevated MIC Values of Imidazole Drugs against Aspergillus fumigatus Isolates with TR34/L98H/S297T/F495I Mutation.

Authors:  Yong Chen; Zongwei Li; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Xueting Su; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Guangbin Qiu; Siyao Wang; Xiaodong Jia; Zhongyi Lu; Mandong Hu; Liuyu Huang; Paul E Verweij; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

8.  Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains.

Authors:  Mahdi Abastabar; Nooshin Rahimi; Jacques F Meis; Narges Aslani; Sadegh Khodavaisy; Mojtaba Nabili; Ali Rezaei-Matehkolaei; Koichi Makimura; Hamid Badali
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

Review 9.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

10.  In Vitro Activities of Five Antifungal Drugs Against Opportunistic Agents of Aspergillus Nigri Complex.

Authors:  Hamid Badali; Hamed Fakhim; Fereshteh Zarei; Mojtaba Nabili; Afsane Vaezi; Nafiseh Poorzad; Somayeh Dolatabadi; Hossein Mirhendi
Journal:  Mycopathologia       Date:  2015-11-28       Impact factor: 2.574
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