Literature DB >> 25896700

Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.

Musang Liu1, Rong Zeng1, Lili Zhang1, Dongmei Li2, Guixia Lv1, Yongnian Shen1, Hailin Zheng1, Qiangqiang Zhang3, Jingjun Zhao4, Nan Zheng5, Weida Liu6.   

Abstract

Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previously in China. The fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carries a new G432A mutation.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25896700      PMCID： PMC4468671          DOI： 10.1128/AAC.00003-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  42 in total

1.  Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India.

Authors:  Anuradha Chowdhary; Cheshta Sharma; Shallu Kathuria; Ferry Hagen; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2013-10-01       Impact factor: 5.790

Review 2.  [Azole resistance in Aspergillus fumigatus - epidemiology and detection in immunocompromised patients in Germany].

Authors:  D Buchheidt; B Spiess; O A Cornely; M J G T Vehreschild; A Hamprecht; P-M Rath; J Steinmann; U Groß; O Bader; M Lauten; M Reinwald; W-K Hofmann
Journal:  Dtsch Med Wochenschr       Date:  2014-06-10       Impact factor: 0.628

3.  Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species.

Authors:  E Mellado; T M Diaz-Guerra; M Cuenca-Estrella; J L Rodriguez-Tudela
Journal:  J Clin Microbiol       Date:  2001-07       Impact factor: 5.948

4.  First detection of TR46/Y121F/T289A and TR34/L98H alterations in Aspergillus fumigatus isolates from azole-naive patients in Denmark despite negative findings in the environment.

Authors:  K M T Astvad; R H Jensen; T M Hassan; E G Mathiasen; G M Thomsen; U G Pedersen; M Christensen; O Hilberg; M C Arendrup
Journal:  Antimicrob Agents Chemother       Date:  2014-06-16       Impact factor: 5.191

5.  Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use?

Authors:  Paul E Verweij; Eveline Snelders; Gert H J Kema; Emilia Mellado; Willem J G Melchers
Journal:  Lancet Infect Dis       Date:  2009-12       Impact factor: 25.071

6.  Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania.

Authors:  Anuradha Chowdhary; Cheshta Sharma; Mara van den Boom; Jan Bart Yntema; Ferry Hagen; Paul E Verweij; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2014-07-07       Impact factor: 5.790

7.  Azole-resistant Aspergillus fumigatus in the environment of northern Italy, May 2011 to June 2012.

Authors:  A Prigitano; V Venier; M Cogliati; G De Lorenzis; M C Esposto; A M Tortorano
Journal:  Euro Surveill       Date:  2014-03-27

Review 8.  Breakpoints for antifungal agents: an update from EUCAST focussing on echinocandins against Candida spp. and triazoles against Aspergillus spp.

Authors:  Maiken C Arendrup; Manuel Cuenca-Estrella; Cornelia Lass-Flörl; William W Hope
Journal:  Drug Resist Updat       Date:  2014-01-27       Impact factor: 18.500

9.  Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011-2013.

Authors:  Cau D Pham; Errol Reiss; Ferry Hagen; Jacques F Meis; Shawn R Lockhart
Journal:  Emerg Infect Dis       Date:  2014-09       Impact factor: 6.883

10.  In vitro susceptibility of Aspergillus fumigatus to isavuconazole: correlation with itraconazole, voriconazole, and posaconazole.

Authors:  Lea Gregson; Joanne Goodwin; Adam Johnson; Laura McEntee; Caroline B Moore; Malcolm Richardson; William W Hope; Susan J Howard
Journal:  Antimicrob Agents Chemother       Date:  2013-09-16       Impact factor: 5.191
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  28 in total

1.  Epidemiology and Molecular Characterizations of Azole Resistance in Clinical and Environmental Aspergillus fumigatus Isolates from China.

Authors:  Yong Chen; Zhongyi Lu; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Zhiyao Bao; Guangbin Qiu; Mingsheng Song; Qing Zhang; Lin Liu; Mandong Hu; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Changjian Zhang; Yansong Sun; Paul E Verweij; Liuyu Huang; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

2.  Triazole Antifungal Susceptibility Patterns among Aspergillus Species in Québec, Canada.

Authors:  Matthew P Cheng; Alexander Lawandi; Todd C Lee; Philippe J Dufresne; Danila Seidel; Paul E Verweij; Oliver A Cornely; Donald C Sheppard
Journal:  J Clin Microbiol       Date:  2019-05-24       Impact factor: 5.948

Review 3.  Aspergillus fumigatus and aspergillosis: From basics to clinics.

Authors:  A Arastehfar; A Carvalho; J Houbraken; L Lombardi; R Garcia-Rubio; J D Jenks; O Rivero-Menendez; R Aljohani; I D Jacobsen; J Berman; N Osherov; M T Hedayati; M Ilkit; D James-Armstrong; T Gabaldón; J Meletiadis; M Kostrzewa; W Pan; C Lass-Flörl; D S Perlin; M Hoenigl
Journal:  Stud Mycol       Date:  2021-05-10       Impact factor: 16.097

4.  Elevated MIC Values of Imidazole Drugs against Aspergillus fumigatus Isolates with TR34/L98H/S297T/F495I Mutation.

Authors:  Yong Chen; Zongwei Li; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Xueting Su; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Guangbin Qiu; Siyao Wang; Xiaodong Jia; Zhongyi Lu; Mandong Hu; Liuyu Huang; Paul E Verweij; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

5.  Contemporary Gene Flow is a Major Force Shaping the Aspergillus fumigatus Population in Auckland, New Zealand.

Authors:  Greg A Korfanty; Lisa Teng; Nicole Pum; Jianping Xu
Journal:  Mycopathologia       Date:  2019-07-15       Impact factor: 2.574

6.  Effects of Itraconazole and Micafungin on Aspergillus fumigatus Biofilms.

Authors:  Musang Liu; Hailin Zheng; Rong Zeng; Guanzhao Liang; Nan Zheng; Weida Liu
Journal:  Mycopathologia       Date:  2021-05-06       Impact factor: 2.574

7.  A Novel Broad Allele-Specific TaqMan Real-Time PCR Method To Detect Triazole-Resistant Strains of Aspergillus fumigatus, Even with a Very Low Percentage of Triazole-Resistant Cells Mixed with Triazole-Susceptible Cells.

Authors:  Qian Wang; Dimitrios P Kontoyiannis; Ruoyu Li; Wei Chen; Dingfang Bu; Wei Liu
Journal:  J Clin Microbiol       Date:  2019-08-26       Impact factor: 5.948

Review 8.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

9.  Comparison of Two Typing Methods for Characterization of Azole Resistance in Aspergillus fumigatus from Potting Soil Samples in a Chinese Hospital.

Authors:  Hong Fan; Yong Chen; Liping Duan; Jingya Zhao; Chunping Qin; Haifeng Li; Jinke Sun; Li Han
Journal:  Antimicrob Agents Chemother       Date:  2020-01-27       Impact factor: 5.191

Review 10.  Epidemiology of fungal infections in China.

Authors:  Min Chen; Yuan Xu; Nan Hong; Yali Yang; Wenzhi Lei; Lin Du; Jingjun Zhao; Xia Lei; Lin Xiong; Langqi Cai; Hui Xu; Weihua Pan; Wanqing Liao
Journal:  Front Med       Date:  2018-01-11       Impact factor: 4.592
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