Literature DB >> 24719446

Simple, low-cost molecular assays for TR34/L98H mutations in the cyp51A gene for rapid detection of triazole-resistant Aspergillus fumigatus isolates.

Suhail Ahmad1, Ziauddin Khan2, Ferry Hagen3, Jacques F Meis4.   

Abstract

Simple, low-cost PCR/PCR-restriction fragment length polymorphism (RFLP) assays targeting cyp51A promoter and codon 98 regions were developed for the detection of triazole-resistant Aspergillus fumigatus strains carrying TR34/L98H mutations. The assays were evaluated using 40 itraconazole-susceptible isolates and 35 itraconazole-resistant isolates. The prevalence of TR34/L98H mutations in clinical/environmental A. fumigatus isolates may now be determined easily from resource-poor settings.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24719446      PMCID： PMC4042779          DOI： 10.1128/JCM.00408-14

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  20 in total

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Journal:  Antimicrob Agents Chemother       Date:  2011-10-17       Impact factor: 5.191

2.  Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America.

Authors:  Thomas J Walsh; Elias J Anaissie; David W Denning; Raoul Herbrecht; Dimitrios P Kontoyiannis; Kieren A Marr; Vicki A Morrison; Brahm H Segal; William J Steinbach; David A Stevens; Jo-Anne van Burik; John R Wingard; Thomas F Patterson
Journal:  Clin Infect Dis       Date:  2008-02-01       Impact factor: 9.079

3.  Analysis of endonuclease R-EcoRI fragments of DNA from lambdoid bacteriophages and other viruses by agarose-gel electrophoresis.

Authors:  R B Helling; H M Goodman; H W Boyer
Journal:  J Virol       Date:  1974-11       Impact factor: 5.103

4.  A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

Authors:  E Mellado; G Garcia-Effron; L Alcázar-Fuoli; W J G Melchers; P E Verweij; M Cuenca-Estrella; J L Rodríguez-Tudela
Journal:  Antimicrob Agents Chemother       Date:  2007-03-19       Impact factor: 5.191

5.  Use of epidemiological cutoff values to examine 9-year trends in susceptibility of Aspergillus species to the triazoles.

Authors:  M Pfaller; L Boyken; R Hollis; J Kroeger; S Messer; S Tendolkar; D Diekema
Journal:  J Clin Microbiol       Date:  2010-12-01       Impact factor: 5.948

6.  Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene.

Authors:  Shawn R Lockhart; João P Frade; Kizee A Etienne; Michael A Pfaller; Daniel J Diekema; S Arunmozhi Balajee
Journal:  Antimicrob Agents Chemother       Date:  2011-06-20       Impact factor: 5.191

7.  Novel mixed-format real-time PCR assay to detect mutations conferring resistance to triazoles in Aspergillus fumigatus and prevalence of multi-triazole resistance among clinical isolates in the Netherlands.

Authors:  Corné H W Klaassen; Hanneke A de Valk; Ilse M Curfs-Breuker; Jacques F Meis
Journal:  J Antimicrob Chemother       Date:  2010-02-18       Impact factor: 5.790

8.  Detection of Aspergillus fumigatus-specific DNA, (1-3)-beta-D-glucan and galactomannan in serum and bronchoalveolar lavage specimens of experimentally infected rats.

Authors:  Z U Khan; S Ahmad; A M Theyyathel
Journal:  Mycoses       Date:  2008-03       Impact factor: 4.377

9.  High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease.

Authors:  David W Denning; Steven Park; Cornelia Lass-Florl; Marcin G Fraczek; Marie Kirwan; Robin Gore; Jaclyn Smith; Ahmed Bueid; Caroline B Moore; Paul Bowyer; David S Perlin
Journal:  Clin Infect Dis       Date:  2011-05       Impact factor: 9.079

10.  Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.

Authors:  Susan J Howard; Dasa Cerar; Michael J Anderson; Ahmed Albarrag; Matthew C Fisher; Alessandro C Pasqualotto; Michel Laverdiere; Maiken C Arendrup; David S Perlin; David W Denning
Journal:  Emerg Infect Dis       Date:  2009-07       Impact factor: 6.883
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  8 in total

Review 1.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

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Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

2.  Quantitative Analysis of Single-Nucleotide Polymorphism for Rapid Detection of TR34/L98H- and TR46/Y121F/T289A-Positive Aspergillus fumigatus Isolates Obtained from Patients in Iran from 2010 to 2014.

Authors:  Faezeh Mohammadi; Seyed Jamal Hashemi; Jan Zoll; Willem J G Melchers; Haleh Rafati; Parvin Dehghan; Sasan Rezaie; Ali Tolooe; Yalda Tamadon; Henrich A van der Lee; Paul E Verweij; Seyedmojtaba Seyedmousavi
Journal:  Antimicrob Agents Chemother       Date:  2015-11-02       Impact factor: 5.191

Review 3.  Recent Advances in Diagnosing Chronic Pulmonary Aspergillosis.

Authors:  Takahiro Takazono; Koichi Izumikawa
Journal:  Front Microbiol       Date:  2018-08-17       Impact factor: 5.640

Review 4.  Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside.

Authors:  Justin Beardsley; Catriona L Halliday; Sharon C-A Chen; Tania C Sorrell
Journal:  Future Microbiol       Date:  2018-08-16       Impact factor: 3.165

5.  Population structure and molecular genetic characterization of clinical Candida tropicalis isolates from a tertiary-care hospital in Kuwait reveal infections with unique strains.

Authors:  Khaled Al-Obaid; Mohammad Asadzadeh; Suhail Ahmad; Ziauddin Khan
Journal:  PLoS One       Date:  2017-08-30       Impact factor: 3.240

6.  Surveillance for Azole-Resistant Aspergillus fumigatus in a Centralized Diagnostic Mycology Service, London, United Kingdom, 1998-2017.

Authors:  Alireza Abdolrasouli; Michael A Petrou; Hyun Park; Johanna L Rhodes; Timothy M Rawson; Luke S P Moore; Hugo Donaldson; Alison H Holmes; Matthew C Fisher; Darius Armstrong-James
Journal:  Front Microbiol       Date:  2018-09-20       Impact factor: 5.640

7.  Triazole-Resistant Aspergillus fumigatus from Fungicide-Experienced Soils in Naivasha Subcounty and Nairobi County, Kenya.

Authors:  Edson K Kemoi; Andrew Nyerere; Christine C Bii
Journal:  Int J Microbiol       Date:  2018-06-26

Review 8.  Molecular Markers of Antifungal Resistance: Potential Uses in Routine Practice and Future Perspectives.

Authors:  Guillermo Garcia-Effron
Journal:  J Fungi (Basel)       Date:  2021-03-09
  8 in total

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