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Literature DB >> 2366628

Elevated levels of nonesterified fatty acids in the myocardium of alloxan diabetic rats.

J Chattopadhyay¹, E W Thompson, H H Schmid.

Abstract

Myocardial nonesterified fatty acids (NEFA) increase markedly within the first two days after the induction of insulin-dependent diabetes mellitus in rats by intravenous injection of alloxan. After initial variability, NEFA levels in diabetic hearts remain constant at approximately 450 nmol/g tissue (16 nmol/mumol lipid P), which is about three times higher than that in control hearts. Nonesterified linoleic acid is significantly increased in diabetic heart whereas both arachidonic and docosahexaenoic acids are decreased compared to controls.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2366628 DOI： 10.1007/bf02544338

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

46 in total

1. EFFECTS OF ALLOXAN DIABETES AND ADRENALINE ON CONCENTRATIONS OF FREE FATTY ACIDS IN RAT HEART AND DIAPHRAGM MUSCLES.

Authors: P B GARLAND; P J RANDLE
Journal: Nature Date: 1963-07-27 Impact factor: 49.962

2. Lipid alterations in isolated, working rat hearts during ischemia and reperfusion: its relation to myocardial damage.

Authors: M van Bilsen; G J van der Vusse; P H Willemsen; W A Coumans; T H Roemen; R S Reneman
Journal: Circ Res Date: 1989-02 Impact factor: 17.367

3. Relation between serum-free-fatty acids and arrhythmias and death after acute myocardial infarction.

Authors: M F Oliver; V A Kurien; T W Greenwood
Journal: Lancet Date: 1968-04-06 Impact factor: 79.321

4. Free fatty acids and myocardial function in perfused rat hearts.

Authors: A H Henderson; R J Craig; R Gorlin; E H Sonnenblick
Journal: Cardiovasc Res Date: 1970-10 Impact factor: 10.787

5. Structural manifestations of diabetic cardiomyopathy in the rat and its reversal by insulin treatment.

Authors: E W Thompson
Journal: Am J Anat Date: 1988-07

Review 6. Influence of free fatty acids on myocardial oxygen consumption and ischemic injury.

Authors: H Vik-Mo; O D Mjøs
Journal: Am J Cardiol Date: 1981-08 Impact factor: 2.778

7. Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusion.

Authors: R M Denton; P J Randle
Journal: Biochem J Date: 1967-08 Impact factor: 3.857

8. Arachidonic acid deficiency in streptozotocin-induced diabetes.

Authors: R T Holman; S B Johnson; J M Gerrard; S M Mauer; S Kupcho-Sandberg; D M Brown
Journal: Proc Natl Acad Sci U S A Date: 1983-04 Impact factor: 11.205

9. Arteriosclerosis obliterans and associated risk factors in insulin-dependent and non-insulin-dependent diabetes.

Authors: K W Beach; D E Strandness
Journal: Diabetes Date: 1980-11 Impact factor: 9.461

10. Adenosine 3',5'cyclic monophosphate in adipose tissue of diabetic rats.

Authors: R J Schimmel
Journal: Biochim Biophys Acta Date: 1976-12-21

5 in total

Review 1. Metabolic disturbances in diabetic cardiomyopathy.

Authors: B Rodrigues; M C Cam; J H McNeill
Journal: Mol Cell Biochem Date: 1998-03 Impact factor: 3.396

Review 2. Lipotoxicity in the heart.

Authors: Nica M Borradaile; Jean E Schaffer
Journal: Curr Hypertens Rep Date: 2005-12 Impact factor: 5.369