OBJECTIVE: Traumatic brain injury (TBI) is an epigenetic risk factor for Alzheimer's disease (AD) and amyloid β (Aβ) deposition is observed histopathologically in the traumatized brain. This study was conducted to detect cerebral Aβ deposition using amyloid positron emission tomography (PET) in patients with neuropsychological impairment after TBI. METHODS: Twelve patients with post-traumatic neuropsychological impairment (11 men and one woman, age range = 21-78 years) were examined using Pittsburgh Compound B ((11)C-PIB) PET at the chronic stage after TBI (range = 5-129 months). RESULTS: (11)C-PIB was positive in three patients and negative in the other nine patients. There was no correlation between (11)C-PIB deposition and the severity of injury; initial CT findings; elapsed time from the injury; and neuropsychological test scores. CONCLUSIONS: The absence of Aβ deposition in many patients with chronic neuropsychological impairment after TBI does not support the premise that Aβ pathology progresses over time in the traumatized brain. Early and sequential (11)C-PIB PET examination may clarify the time course of Aβ deposition in the traumatized brain and the relationship between traumatic brain insult and subsequent neuropsychological impairment.
OBJECTIVE:Traumatic brain injury (TBI) is an epigenetic risk factor for Alzheimer's disease (AD) and amyloid β (Aβ) deposition is observed histopathologically in the traumatized brain. This study was conducted to detect cerebral Aβ deposition using amyloid positron emission tomography (PET) in patients with neuropsychological impairment after TBI. METHODS: Twelve patients with post-traumatic neuropsychological impairment (11 men and one woman, age range = 21-78 years) were examined using Pittsburgh Compound B ((11)C-PIB) PET at the chronic stage after TBI (range = 5-129 months). RESULTS: (11)C-PIB was positive in three patients and negative in the other nine patients. There was no correlation between (11)C-PIB deposition and the severity of injury; initial CT findings; elapsed time from the injury; and neuropsychological test scores. CONCLUSIONS: The absence of Aβ deposition in many patients with chronic neuropsychological impairment after TBI does not support the premise that Aβ pathology progresses over time in the traumatized brain. Early and sequential (11)C-PIB PET examination may clarify the time course of Aβ deposition in the traumatized brain and the relationship between traumatic brain insult and subsequent neuropsychological impairment.
Authors: Elisabeth A Wilde; Sylvain Bouix; David F Tate; Alexander P Lin; Mary R Newsome; Brian A Taylor; James R Stone; James Montier; Samuel E Gandy; Brian Biekman; Martha E Shenton; Gerald York Journal: Brain Imaging Behav Date: 2015-09 Impact factor: 3.978
Authors: Andrea L C Schneider; Elizabeth Selvin; Menglu Liang; Lawrence Latour; L Christine Turtzo; Silvia Koton; Josef Coresh; Thomas Mosley; Christopher T Whitlow; Yun Zhou; Dean F Wong; Geoffrey Ling; Rebecca F Gottesman Journal: J Neurotrauma Date: 2019-05-23 Impact factor: 5.269
Authors: Franck Amyot; David B Arciniegas; Michael P Brazaitis; Kenneth C Curley; Ramon Diaz-Arrastia; Amir Gandjbakhche; Peter Herscovitch; Sidney R Hinds; Geoffrey T Manley; Anthony Pacifico; Alexander Razumovsky; Jason Riley; Wanda Salzer; Robert Shih; James G Smirniotopoulos; Derek Stocker Journal: J Neurotrauma Date: 2015-09-30 Impact factor: 5.269
Authors: Denes Agoston; Peethambaran Arun; Patrick Bellgowan; Steven Broglio; Robert Cantu; David Cook; Uade Olaghere da Silva; Dara Dickstein; Gregory Elder; Elizabeth Fudge; Sam Gandy; Jessica Gill; John F Glenn; Raj K Gupta; Sidney Hinds; Stuart Hoffman; Theresa Lattimore; Alexander Lin; Kun Ping Lu; Joseph Maroon; David Okonkwo; Daniel Perl; Meghan Robinson; Charles Rosen; Douglas Smith Journal: J Neurotrauma Date: 2017-09 Impact factor: 5.269
Authors: Diana Miszczuk; Konrad J Dębski; Heikki Tanila; Katarzyna Lukasiuk; Asla Pitkänen Journal: Mol Neurobiol Date: 2015-12-15 Impact factor: 5.590