Literature DB >> 23649940

Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus.

Claudia C König1, Kirstin Scherlach, Volker Schroeckh, Fabian Horn, Sandor Nietzsche, Axel A Brakhage, Christian Hertweck.   

Abstract

Stimulating encounter: The intimate, physical interaction between the soil-derived bacterium Streptomyces rapamycinicus and the human pathogenic fungus Aspergillus fumigatus led to the activation of an otherwise silent polyketide synthase (PKS) gene cluster coding for an unusual prenylated polyphenol (fumicycline A). The meroterpenoid pathway is regulated by a pathway-specific activator gene as well as by epigenetic factors.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23649940     DOI： 10.1002/cbic.201300070

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  40 in total

Review 1.  Taxonomy, Physiology, and Natural Products of Actinobacteria.

Authors:  Essaid Ait Barka; Parul Vatsa; Lisa Sanchez; Nathalie Gaveau-Vaillant; Cedric Jacquard; Jan P Meier-Kolthoff; Hans-Peter Klenk; Christophe Clément; Yder Ouhdouch; Gilles P van Wezel
Journal:  Microbiol Mol Biol Rev       Date:  2015-11-25       Impact factor: 11.056

Review 2.  Strategies for mining fungal natural products.

Authors:  Philipp Wiemann; Nancy P Keller
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-22       Impact factor: 3.346

Review 3.  Recent advances in natural product discovery.

Authors:  Yunzi Luo; Ryan E Cobb; Huimin Zhao
Journal:  Curr Opin Biotechnol       Date:  2014-09-26       Impact factor: 9.740

4.  Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus.

Authors:  Juliane Macheleidt; Kirstin Scherlach; Toni Neuwirth; Wolfgang Schmidt-Heck; Maria Straßburger; Joseph Spraker; Joshua A Baccile; Frank C Schroeder; Nancy P Keller; Christian Hertweck; Thorsten Heinekamp; Axel A Brakhage
Journal:  Mol Microbiol       Date:  2015-03-11       Impact factor: 3.501

Review 5.  Using natural products for drug discovery: the impact of the genomics era.

Authors:  Mingzi M Zhang; Yuan Qiao; Ee Lui Ang; Huimin Zhao
Journal:  Expert Opin Drug Discov       Date:  2017-03-14       Impact factor: 6.098

Review 6.  Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012-2018).

Authors:  Jillian Romsdahl; Clay C C Wang
Journal:  Medchemcomm       Date:  2019-04-26       Impact factor: 3.597

7.  Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity.

Authors:  Nicholas Raffa; Tae Hyung Won; Andrew Sukowaty; Kathleen Candor; Chengsen Cui; Saayak Halder; Mingji Dai; Julio A Landero-Figueroa; Frank C Schroeder; Nancy P Keller
Journal:  Proc Natl Acad Sci U S A       Date:  2021-02-23       Impact factor: 11.205

Review 8.  Symbiosis-inspired approaches to antibiotic discovery.

Authors:  Navid Adnani; Scott R Rajski; Tim S Bugni
Journal:  Nat Prod Rep       Date:  2017-07-06       Impact factor: 13.423

9.  Knock-down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi.

Authors:  Lena Studt; Sarah M Rösler; Immo Burkhardt; Birgit Arndt; Michael Freitag; Hans-Ulrich Humpf; Jeroen S Dickschat; Bettina Tudzynski
Journal:  Environ Microbiol       Date:  2016-07-18       Impact factor: 5.491

Review 10.  Lessons learned from the transformation of natural product discovery to a genome-driven endeavor.

Authors:  Caitlin D Deane; Douglas A Mitchell
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-19       Impact factor: 3.346
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.