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Literature DB >> 23648270

New pathways to control inflammatory responses in adipose tissue.

Rand T Akasheh¹, Jingbo Pang, Jason M York, Giamila Fantuzzi.

Abstract

Obesity is characterized by the presence of chronic inflammation in adipose tissue, particularly in the visceral compartment, that has been causally linked to development of obesity-associated comorbidities. This link can be either direct or indirect, through induction of insulin resistance. This review summarizes recent evidence on potential pharmacological targets of adipose tissue inflammation, with emphasis on mediators that are being studied for intervention in chronic inflammatory diseases and are therefore viable therapeutical candidates. Specifically, we discuss evidence on the role of the inflammasome and its downstream products as a potential target for anti-inflammatory strategies as well as T regulatory (Treg) cells and mediators involved in the resolution phase of inflammation such as resolvins, protectins, annexin A1 (ANXA1) and galectins as potential targets for novel agonist therapies.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23648270 PMCID： PMC3732512 DOI： 10.1016/j.coph.2013.04.008

Source DB: PubMed Journal: Curr Opin Pharmacol ISSN： 1471-4892 Impact factor: 5.547

47 in total

Review 1. Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis.

Authors: Amiram Ariel; Orly Timor
Journal: J Pathol Date: 2013-01 Impact factor: 7.996

2. Inflammasome is a central player in the induction of obesity and insulin resistance.

Authors: Rinke Stienstra; Janna A van Diepen; Cees J Tack; Md Hasan Zaki; Frank L van de Veerdonk; Deshani Perera; Geoffrey A Neale; Guido J Hooiveld; Anneke Hijmans; Irene Vroegrijk; Sjoerd van den Berg; Johannes Romijn; Patrick C N Rensen; Leo A B Joosten; Mihai G Netea; Thirumala-Devi Kanneganti
Journal: Proc Natl Acad Sci U S A Date: 2011-08-29 Impact factor: 11.205

3. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.

Authors: Rinke Stienstra; Leo A B Joosten; Tim Koenen; Berry van Tits; Janna A van Diepen; Sjoerd A A van den Berg; Patrick C N Rensen; Peter J Voshol; Giamilla Fantuzzi; Anneke Hijmans; Sander Kersten; Michael Müller; Wim B van den Berg; Nico van Rooijen; Martin Wabitsch; Bart-Jan Kullberg; Jos W M van der Meer; Thirumala Kanneganti; Cees J Tack; Mihai G Netea
Journal: Cell Metab Date: 2010-12-01 Impact factor: 27.287

4. Serum galectin-3 is elevated in obesity and negatively correlates with glycosylated hemoglobin in type 2 diabetes.

Authors: Johanna Weigert; Markus Neumeier; Josef Wanninger; Sabrina Bauer; Stefan Farkas; Marcus N Scherer; Andreas Schnitzbauer; Andreas Schäffler; Charalampos Aslanidis; Jürgen Schölmerich; Christa Buechler
Journal: J Clin Endocrinol Metab Date: 2010-01-15 Impact factor: 5.958

Review 5. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity.

Authors: Leonie K Heilbronn; Lesley V Campbell
Journal: Curr Pharm Des Date: 2008 Impact factor: 3.116

Review 6. Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.

Authors: Mauro Perretti; Fulvio D'Acquisto
Journal: Nat Rev Immunol Date: 2009-01 Impact factor: 53.106

Review 7. Regulatory T cell induction, migration, and function in transplantation.

Authors: Bryna E Burrell; Yumi Nakayama; Jiangnan Xu; C Colin Brinkman; Jonathan S Bromberg
Journal: J Immunol Date: 2012-11-15 Impact factor: 5.422

8. Advanced lipoxidation end-products mediate lipid-induced glomerular injury: role of receptor-mediated mechanisms.

Authors: Carla Iacobini; Stefano Menini; Carlo Ricci; Angela Scipioni; Viola Sansoni; Giulia Mazzitelli; Samantha Cordone; Carlo Pesce; Francesco Pugliese; Flavia Pricci; Giuseppe Pugliese
Journal: J Pathol Date: 2009-07 Impact factor: 7.996

9. Annexin A1 and the regulation of innate and adaptive immunity.

Authors: Felicity N E Gavins; Michael J Hickey
Journal: Front Immunol Date: 2012-11-27 Impact factor: 7.561

Review 10. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis.

Authors: Katherine M Flegal; Brian K Kit; Heather Orpana; Barry I Graubard
Journal: JAMA Date: 2013-01-02 Impact factor: 56.272

10 in total

1. Exposure to severe famine in the prenatal or postnatal period and the development of diabetes in adulthood: an observational study.

Authors: Ningjian Wang; Jing Cheng; Bing Han; Qin Li; Yi Chen; Fangzhen Xia; Boren Jiang; Michael D Jensen; Yingli Lu
Journal: Diabetologia Date: 2016-11-02 Impact factor: 10.122

Review 2. The pathophysiology of hypertension in patients with obesity.

Authors: Vincent G DeMarco; Annayya R Aroor; James R Sowers
Journal: Nat Rev Endocrinol Date: 2014-04-15 Impact factor: 43.330

3. Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea.

Authors: A Carreras; S X Zhang; E Peris; Z Qiao; Y Wang; I Almendros; D Gozal
Journal: Int J Obes (Lond) Date: 2014-10-09 Impact factor: 5.095

4. Cytokine signaling regulating adipose stromal cell trafficking.

Authors: Yan Zhang; Mikhail G Kolonin
Journal: Adipocyte Date: 2016-08-12 Impact factor: 4.534

5. Specialized proresolution mediators in the bladder: annexin-A1 normalizes inflammation and bladder dysfunction during bladder outlet obstruction.

Authors: Francis M Hughes; Shelby N Harper; Brent D Nosé; Armand Allkanjari; Michael T Zheng; Huixia Jin; J Todd Purves
Journal: Am J Physiol Renal Physiol Date: 2021-08-16

6. Guggulsterone Attenuated Lipopolysaccharide-Induced Inflammatory Responses in Mouse Inner Medullary Collecting Duct-3 Cells.

Authors: Dong-Goo Kim; Gi-Sang Bae; Il-Joo Jo; Sun-Bok Choi; Myoung-Jin Kim; Jun-Hyeok Jeong; Dae-Gil Kang; Ho-Sub Lee; Ho-Joon Song; Sung-Joo Park
Journal: Inflammation Date: 2016-02 Impact factor: 4.092

10. Galectin-1 accelerates high-fat diet-induced obesity by activation of peroxisome proliferator-activated receptor gamma (PPARγ) in mice.

Authors: Jung-Hwan Baek; Da-Hyun Kim; Jaegyeong Lee; Seok-Jun Kim; Kyung-Hee Chun
Journal: Cell Death Dis Date: 2021-01-11 Impact factor: 8.469