Literature DB >> 23125426

Regulatory T cell induction, migration, and function in transplantation.

Bryna E Burrell1, Yumi Nakayama, Jiangnan Xu, C Colin Brinkman, Jonathan S Bromberg.   

Abstract

Regulatory T cells (Treg) are important in maintaining immune homeostasis and in regulating a variety of immune responses, making them attractive targets for modulating immune-related diseases. Success in using induction or transfer of Treg in mice to mediate transplant tolerance suggests Treg-based therapies as mechanisms of long-term drug-free transplant tolerance in human patients. Although more work is needed, critical analyses suggest that key factors in Treg induction, migration, and function are important areas to concentrate investigative efforts and therapeutic development. Elucidation of basic biology will aid in translating data gleaned from mice to humans so that Treg therapies become a reality for patients.

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Year:  2012        PMID： 23125426      PMCID： PMC3490202          DOI： 10.4049/jimmunol.1202027

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  120 in total

1.  CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.

Authors:  R Förster; A Schubel; D Breitfeld; E Kremmer; I Renner-Müller; E Wolf; M Lipp
Journal:  Cell       Date:  1999-10-01       Impact factor: 41.582

2.  Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.

Authors:  Hyung W Lim; Peter Hillsamer; Chang H Kim
Journal:  J Clin Invest       Date:  2004-12       Impact factor: 14.808

3.  Evidence for immune regulation in the induction of transplantation tolerance: a conditional but limited role for IL-4.

Authors:  A Bushell; M Niimi; P J Morris; K J Wood
Journal:  J Immunol       Date:  1999-02-01       Impact factor: 5.422

4.  CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment.

Authors:  X X Zheng; T G Markees; W W Hancock; Y Li; D L Greiner; X C Li; J P Mordes; M H Sayegh; A A Rossini; T B Strom
Journal:  J Immunol       Date:  1999-04-15       Impact factor: 5.422

5.  Regulatory T cell lineage specification by the forkhead transcription factor foxp3.

Authors:  Jason D Fontenot; Jeffrey P Rasmussen; Luke M Williams; James L Dooley; Andrew G Farr; Alexander Y Rudensky
Journal:  Immunity       Date:  2005-03       Impact factor: 31.745

6.  Cellular and molecular characterization of the scurfy mouse mutant.

Authors:  L B Clark; M W Appleby; M E Brunkow; J E Wilkinson; S F Ziegler; F Ramsdell
Journal:  J Immunol       Date:  1999-03-01       Impact factor: 5.422

7.  Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.

Authors:  David C Gondek; Li-Fan Lu; Sergio A Quezada; Shimon Sakaguchi; Randolph J Noelle
Journal:  J Immunol       Date:  2005-02-15       Impact factor: 5.422

8.  A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance.

Authors:  R Josien; P Douillard; C Guillot; M Müschen; I Anegon; J Chetritt; S Menoret; C Vignes; J P Soulillou; M C Cuturi
Journal:  J Clin Invest       Date:  1998-12-01       Impact factor: 14.808

9.  Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor.

Authors:  Iris Lee; Liqing Wang; Andrew D Wells; Martin E Dorf; Engin Ozkaynak; Wayne W Hancock
Journal:  J Exp Med       Date:  2005-04-04       Impact factor: 14.307

10.  Molecular mechanisms of lymphocyte homing to peripheral lymph nodes.

Authors:  R A Warnock; S Askari; E C Butcher; U H von Andrian
Journal:  J Exp Med       Date:  1998-01-19       Impact factor: 14.307
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  28 in total

1.  Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells.

Authors:  Cong Wu; Yi Zhang; Yingming Jiang; Quanxing Wang; Yao Long; Chunmei Wang; Xuetao Cao; Guoyou Chen
Journal:  Cell Mol Immunol       Date:  2013-07-22       Impact factor: 11.530

2.  Adoptive Cell Therapy with Tregs to Improve Transplant Outcomes: The Promise and the Stumbling Blocks.

Authors:  Mohamed B Ezzelarab; Angus W Thomson
Journal:  Curr Transplant Rep       Date:  2016-10-25

Review 3.  Haploidentical SCT: the mechanisms underlying the crossing of HLA barriers.

Authors:  Y-J Chang; X-J Huang
Journal:  Bone Marrow Transplant       Date:  2014-02-24       Impact factor: 5.483

Review 4.  Complement as a multifaceted modulator of kidney transplant injury.

Authors:  Paolo Cravedi; Peter S Heeger
Journal:  J Clin Invest       Date:  2014-06-02       Impact factor: 14.808

5.  Sequential monitoring and stability of ex vivo-expanded autologous and nonautologous regulatory T cells following infusion in nonhuman primates.

Authors:  H Zhang; H Guo; L Lu; A F Zahorchak; R W Wiseman; G Raimondi; D K C Cooper; M B Ezzelarab; A W Thomson
Journal:  Am J Transplant       Date:  2015-03-17       Impact factor: 8.086

6.  Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation.

Authors:  Esilida Sula Karreci; Siawosh K Eskandari; Farokh Dotiwala; Sujit K Routray; Ahmed T Kurdi; Jean Pierre Assaker; Pavlo Luckyanchykov; Albana B Mihali; Omar Maarouf; Thiago J Borges; Abdullah Alkhudhayri; Kruti R Patel; Amr Radwan; Irene Ghobrial; Martina McGrath; Anil Chandraker; Leonardo V Riella; Wassim Elyaman; Reza Abdi; Judy Lieberman; Jamil Azzi
Journal:  JCI Insight       Date:  2017-11-02

7.  The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas.

Authors:  Andrea Peloso; Luca Urbani; Paolo Cravedi; Ravi Katari; Panagiotis Maghsoudlou; Mario Enrique Alvarez Fallas; Valeria Sordi; Antonio Citro; Carolina Purroy; Guoguang Niu; John P McQuilling; Sivanandane Sittadjody; Alan C Farney; Samy S Iskandar; Joao P Zambon; Jeffrey Rogers; Robert J Stratta; Emmanuel C Opara; Lorenzo Piemonti; Cristina M Furdui; Shay Soker; Paolo De Coppi; Giuseppe Orlando
Journal:  Ann Surg       Date:  2016-07       Impact factor: 12.969

8.  Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.

Authors:  M B Ezzelarab; H Zhang; H Guo; L Lu; A F Zahorchak; R W Wiseman; M A Nalesnik; J K Bhama; D K C Cooper; A W Thomson
Journal:  Am J Transplant       Date:  2016-03-17       Impact factor: 8.086

Review 9.  Complement regulation of T-cell alloimmunity.

Authors:  Paolo Cravedi; William van der Touw; Peter S Heeger
Journal:  Semin Nephrol       Date:  2013-11       Impact factor: 5.299

10.  Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD.

Authors:  Benjamin M Matta; Dawn K Reichenbach; Xiaoli Zhang; Lisa Mathews; Brent H Koehn; Gaelen K Dwyer; Jeremy M Lott; Franziska M Uhl; Dietmar Pfeifer; Colby J Feser; Michelle J Smith; Quan Liu; Robert Zeiser; Bruce R Blazar; Hēth R Turnquist
Journal:  Blood       Date:  2016-05-24       Impact factor: 22.113
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