BACKGROUND: For the large population of elderly patients with cardiovascular disease, it is crucial to identify clinically relevant measures of biological age and their contribution to risk. Frailty is denoting decreased physiological reserves and increased vulnerability. We analysed the manner in which the variable frailty is associated with 1-year outcomes for elderly non-ST-segment elevation myocardial infarction (NSTEMI) patients. METHODS AND RESULTS: Patients aged 75 years or older, with diagnosed NSTEMI were included at three centres, and clinical data including judgment of frailty were collected prospectively. Frailty was defined according to the Canadian Study of Health and Aging Clinical Frailty Scale. Of 307 patients, 149 (48.5%) were considered frail. By Cox regression analyses, frailty was found to be independently associated with 1-year mortality after adjusting for cardiovascular risk and comorbid conditions (hazard ratio 4.3, 95% CI 2.4-7.8). The time to the first event was significantly shorter for frail patients than for nonfrail (34 days, 95% CI 10-58, p = 0.005). CONCLUSIONS: Frailty is strongly and independently associated with 1-year mortality. The combined use of frailty and comorbidity may constitute an important risk prediction concept in regard to cardiovascular patients with complex needs.
BACKGROUND: For the large population of elderly patients with cardiovascular disease, it is crucial to identify clinically relevant measures of biological age and their contribution to risk. Frailty is denoting decreased physiological reserves and increased vulnerability. We analysed the manner in which the variable frailty is associated with 1-year outcomes for elderly non-ST-segment elevation myocardial infarction (NSTEMI) patients. METHODS AND RESULTS:Patients aged 75 years or older, with diagnosed NSTEMI were included at three centres, and clinical data including judgment of frailty were collected prospectively. Frailty was defined according to the Canadian Study of Health and Aging Clinical Frailty Scale. Of 307 patients, 149 (48.5%) were considered frail. By Cox regression analyses, frailty was found to be independently associated with 1-year mortality after adjusting for cardiovascular risk and comorbid conditions (hazard ratio 4.3, 95% CI 2.4-7.8). The time to the first event was significantly shorter for frail patients than for nonfrail (34 days, 95% CI 10-58, p = 0.005). CONCLUSIONS: Frailty is strongly and independently associated with 1-year mortality. The combined use of frailty and comorbidity may constitute an important risk prediction concept in regard to cardiovascular patients with complex needs.
Authors: Gonzalo Luis Alonso Salinas; Marcelo Sanmartin; Marina Pascual Izco; Luis Miguel Rincon; Pablo Pastor Pueyo; Alvaro Marco Del Castillo; Alberto Garcia Guerrero; Pedro Caravaca Perez; Alejandro Recio-Mayoral; Asuncion Camino; Manuel Jimenez-Mena; José Luis Zamorano Journal: Clin Cardiol Date: 2017-07-16 Impact factor: 2.882
Authors: Alejandra Gullón; Francesc Formiga; Jesús Díez-Manglano; José María Mostaza; José María Cepeda; Antonio Pose; Jesús Castiella; Carmen Suárez-Fernández Journal: Intern Emerg Med Date: 2018-09-06 Impact factor: 3.397
Authors: Shelli L Feder; Dena Schulman-Green; John A Dodson; Mary Geda; Kathleen Williams; Michael G Nanna; Heather G Allore; Terrence E Murphy; Mary E Tinetti; Thomas M Gill; Sarwat I Chaudhry Journal: J Aging Health Date: 2015-06-22