Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Transduction of voltage and Ca2+ signals by Slo1 BK channels.

Literature DB >> 23636263

Transduction of voltage and Ca2+ signals by Slo1 BK channels.

Abstract

Large-conductance Ca2+ -and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excellent framework to understand the influences of auxiliary β and γ subunits and regulatory factors such as Mg2+. Recent advances permit elucidation of structural correlates of the biophysical mechanism.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2013 PMID： 23636263 PMCID： PMC3742125 DOI： 10.1152/physiol.00055.2012

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

194 in total

1. Mapping the conformational wave of acetylcholine receptor channel gating.

Authors: C Grosman; M Zhou; A Auerbach
Journal: Nature Date: 2000-02-17 Impact factor: 49.962

2. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.

Authors: R Behrens; A Nolting; F Reimann; M Schwarz; R Waldschütz; O Pongs
Journal: FEBS Lett Date: 2000-05-26 Impact factor: 4.124

3. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels.

Authors: T M Weiger; M H Holmqvist; I B Levitan; F T Clark; S Sprague; W J Huang; P Ge; C Wang; D Lawson; M E Jurman; M A Glucksmann; I Silos-Santiago; P S DiStefano; R Curtis
Journal: J Neurosci Date: 2000-05-15 Impact factor: 6.167

Review 4. Modular assembly of voltage-gated channel proteins: a sequence analysis and phylogenetic study.

Authors: R D Nelson; G Kuan; M H Saier; M Montal
Journal: J Mol Microbiol Biotechnol Date: 1999-11

5. Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism.

Authors: B S Rothberg; K L Magleby
Journal: J Gen Physiol Date: 2000-07-01 Impact factor: 4.086

6. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.

Authors: P Meera; M Wallner; L Toro
Journal: Proc Natl Acad Sci U S A Date: 2000-05-09 Impact factor: 11.205

7. The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells.

Authors: L R Shao; R Halvorsrud; L Borg-Graham; J F Storm
Journal: J Physiol Date: 1999-11-15 Impact factor: 5.182

8. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.

Authors: R Brenner; T J Jegla; A Wickenden; Y Liu; R W Aldrich
Journal: J Biol Chem Date: 2000-03-03 Impact factor: 5.157

9. Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.

Authors: X M Xia; J P Ding; X H Zeng; K L Duan; C J Lingle
Journal: J Neurosci Date: 2000-07-01 Impact factor: 6.167

10. Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel.

Authors: V N Uebele; A Lagrutta; T Wade; D J Figueroa; Y Liu; E McKenna; C P Austin; P B Bennett; R Swanson
Journal: J Biol Chem Date: 2000-07-28 Impact factor: 5.157

41 in total

1. Large-conductance Ca²⁺- and voltage-gated K⁺ channels form and break interactions with membrane lipids during each gating cycle.

Authors: Yutao Tian; Stefan H Heinemann; Toshinori Hoshi
Journal: Proc Natl Acad Sci U S A Date: 2019-04-09 Impact factor: 11.205

Transduction of voltage and Ca2+ signals by Slo1 BK channels.

1. Mapping the conformational wave of acetylcholine receptor channel gating.

2. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.

3. A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels.

Review 4. Modular assembly of voltage-gated channel proteins: a sequence analysis and phylogenetic study.

5. Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism.

6. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.

7. The role of BK-type Ca2+-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells.

8. Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.

9. Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.

10. Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel.

1. Large-conductance Ca²⁺- and voltage-gated K⁺ channels form and break interactions with membrane lipids during each gating cycle.

2. MitoBK_Ca channel is functionally associated with its regulatory β1 subunit in cardiac mitochondria.

Review 3. Regulation of BK Channels by Beta and Gamma Subunits.

4. Structural biology: Ion-channel mechanisms revealed.

Review 5. Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.

Review 6. Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth.

7. Functional regulation of BK potassium channels by γ1 auxiliary subunits.

Review 8. Oxidative modulation of voltage-gated potassium channels.

Review 9. Carbon monoxide--physiology, detection and controlled release.

10. The smooth muscle-type β1 subunit potentiates activation by DiBAC4(3) in recombinant BK channels.