Vivian Gonzalez-Perez1, Christopher J Lingle1. 1. Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA; email: clingle@morpheus.wustl.edu.
Abstract
Ca2+- and voltage-gated K+ channels of large conductance (BK channels) are expressed in a diverse variety of both excitable and inexcitable cells, with functional properties presumably uniquely calibrated for the cells in which they are found. Although some diversity in BK channel function, localization, and regulation apparently arises from cell-specific alternative splice variants of the single pore-forming α subunit ( KCa1.1, Kcnma1, Slo1) gene, two families of regulatory subunits, β and γ, define BK channels that span a diverse range of functional properties. We are just beginning to unravel the cell-specific, physiological roles served by BK channels of different subunit composition.
Ca2+- aical">nd voltage-gated K+ chaical">nnels of large coical">nductaical">nce (n class="Chemical">BK channels) are expressed in a diverse variety of both excitable and inexcitable cells, with functional properties presumably uniquely calibrated for the cells in which they are found. Although some diversity in BK channel function, localization, and regulation apparently arises from cell-specific alternative splice variants of the single pore-forming α subunit ( KCa1.1, Kcnma1, Slo1) gene, two families of regulatory subunits, β and γ, define BK channels that span a diverse range of functional properties. We are just beginning to unravel the cell-specific, physiological roles served by BK channels of different subunit composition.
Entities:
Keywords:
; BK channels; Ca- and voltage-dependent K channels; auxiliary subunits; beta subunits; gamma subunits
Authors: J H Jaggar; G C Wellman; T J Heppner; V A Porter; G J Perez; M Gollasch; T Kleppisch; M Rubart; A S Stevenson; W J Lederer; H J Knot; A D Bonev; M T Nelson Journal: Acta Physiol Scand Date: 1998-12
Authors: Christopher J Lingle; Pedro L Martinez-Espinosa; Aizhen Yang-Hood; Luis E Boero; Shelby Payne; Dora Persic; Babak V-Ghaffari; Maolei Xiao; Yu Zhou; Xiao-Ming Xia; Sonja J Pyott; Mark A Rutherford Journal: Proc Natl Acad Sci U S A Date: 2019-08-26 Impact factor: 11.205
Authors: Vivian Gonzalez-Perez; Pedro L Martinez-Espinosa; Monica Sala-Rabanal; Nikhil Bharadwaj; Xiao-Ming Xia; Albert C Chen; David Alvarado; Jenny K Gustafsson; Hongzhen Hu; Matthew A Ciorba; Christopher J Lingle Journal: Proc Natl Acad Sci U S A Date: 2021-01-19 Impact factor: 12.779