Literature DB >> 10828459

hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.

R Behrens1, A Nolting, F Reimann, M Schwarz, R Waldschütz, O Pongs.   

Abstract

We cloned two beta subunits of large-conductance calcium-activated potassium (BK) channels, hKCNMB3 (BKbeta1) and hKCNMB4 (BKbeta4). Profiling mRNA expression showed that hKCNMB3 expression is enriched in testis and hKCNMB4 expression is very prominent in brain. We coexpressed BK channel alpha (BKalpha) and BKbeta4 subunits in vitro in CHO cells. We compared BKalpha/beta4 mediated currents with those of smooth muscle BKalpha/beta1 channels. BKbeta4 slowed activation kinetics more significantly, led to a steeper apparent calcium sensitivity, and shifted the voltage range of BK current activation to more negative potentials than BKbeta1. BKalpha/beta4 channels were not blocked by 100 nM charybdotoxin or iberiotoxin, and were activated by 17beta-estradiol.

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Year:  2000        PMID： 10828459     DOI： 10.1016/s0014-5793(00)01584-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  136 in total

1.  Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release.

Authors:  H Hu; L R Shao; S Chavoshy; N Gu; M Trieb; R Behrens; P Laake; O Pongs; H G Knaus; O P Ottersen; J F Storm
Journal:  J Neurosci       Date:  2001-12-15       Impact factor: 6.167

Review 2.  Potassium channels in epithelial transport.

Authors:  Richard Warth
Journal:  Pflugers Arch       Date:  2003-04-18       Impact factor: 3.657

3.  Dual and opposing roles of presynaptic Ca2+ influx for spontaneous GABA release from rat medial preoptic nerve terminals.

Authors:  Michael Druzin; David Haage; Evgenya Malinina; Staffan Johansson
Journal:  J Physiol       Date:  2002-07-01       Impact factor: 5.182

Review 4.  Function of K+ channels in the intestinal epithelium.

Authors:  R Warth; J Barhanin
Journal:  J Membr Biol       Date:  2003-05-15       Impact factor: 1.843

5.  The pure anti-oestrogen ICI 182,780 (Faslodex) activates large conductance Ca(2+)-activated K(+) channels in smooth muscle.

Authors:  Gregory M Dick
Journal:  Br J Pharmacol       Date:  2002-08       Impact factor: 8.739

6.  Functional effects of auxiliary beta4-subunit on rat large-conductance Ca(2+)-activated K(+) channel.

Authors:  Tal Soo Ha; Moon-Sun Heo; Chul-Seung Park
Journal:  Biophys J       Date:  2004-05       Impact factor: 4.033

7.  Ca2+-activated K channels in parotid acinar cells: The functional basis for the hyperpolarized activation of BK channels.

Authors:  Victor G Romanenko; Jill Thompson; Ted Begenisich
Journal:  Channels (Austin)       Date:  2010-07-28       Impact factor: 2.581

8.  Intron retention facilitates splice variant diversity in calcium-activated big potassium channel populations.

Authors:  Thomas J Bell; Kevin Y Miyashiro; Jai-Yoon Sul; Peter T Buckley; Miler T Lee; Ron McCullough; Jeanine Jochems; Junhyong Kim; Charles R Cantor; Thomas D Parsons; James H Eberwine
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-15       Impact factor: 11.205

Review 9.  A BK (Slo1) channel journey from molecule to physiology.

Authors:  Gustavo F Contreras; Karen Castillo; Nicolás Enrique; Willy Carrasquel-Ursulaez; Juan Pablo Castillo; Verónica Milesi; Alan Neely; Osvaldo Alvarez; Gonzalo Ferreira; Carlos González; Ramón Latorre
Journal:  Channels (Austin)       Date:  2013-09-11       Impact factor: 2.581

10.  Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site.

Authors:  Qiong-Yao Tang; Zhe Zhang; Xuan-Yu Meng; Meng Cui; Diomedes E Logothetis
Journal:  J Biol Chem       Date:  2014-04-28       Impact factor: 5.157
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