| Literature DB >> 23635770 |
Aleksandra Filipovska1, Oliver Rackham1.
Abstract
Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism across the eukaryotic domain. Recent computational and structural studies have provided new insights into how they recognize RNA, and show that the recognition is sequence-specific and modular. The modular code for RNA-binding by PPR proteins holds great promise for the engineering of new tools to target RNA and identifying RNAs bound by natural PPR proteins.Keywords: RNA-binding; RNA-protein interactions; pentatricopeptide repeat; repeat proteins; synthetic biology
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Year: 2013 PMID: 23635770 PMCID: PMC3858425 DOI: 10.4161/rna.24769
Source DB: PubMed Journal: RNA Biol ISSN: 1547-6286 Impact factor: 4.652