Literature DB >> 23635770

Pentatricopeptide repeats: modular blocks for building RNA-binding proteins.

Aleksandra Filipovska1, Oliver Rackham1.   

Abstract

Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism across the eukaryotic domain. Recent computational and structural studies have provided new insights into how they recognize RNA, and show that the recognition is sequence-specific and modular. The modular code for RNA-binding by PPR proteins holds great promise for the engineering of new tools to target RNA and identifying RNAs bound by natural PPR proteins.

Keywords:  RNA-binding; RNA-protein interactions; pentatricopeptide repeat; repeat proteins; synthetic biology

Mesh:

Substances:

Year:  2013        PMID: 23635770      PMCID: PMC3858425          DOI: 10.4161/rna.24769

Source DB:  PubMed          Journal:  RNA Biol        ISSN: 1547-6286            Impact factor:   4.652


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