Literature DB >> 23623492

Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.

Longhu Zhou1, Franck Amblard, Hongwang Zhang, Tamara R McBrayer, Mervi A Detorio, Tony Whitaker, Steven J Coats, Raymond F Schinazi.   

Abstract

The synthesis of new ribo and 2'-β-C-methyl ribo Janus type nucleosides J-AA, J-AG and J-AU is reported along with their ability to block HCV and HIV replication. Their toxicity was also assessed in Huh7, human lymphocytes, CEM and Vero cells. Published by Elsevier Ltd.

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Year:  2013        PMID： 23623492      PMCID： PMC3704321          DOI： 10.1016/j.bmcl.2013.03.077

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

1.  Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

Authors:  Lieven J Stuyver; Tony Whitaker; Tamara R McBrayer; Brenda I Hernandez-Santiago; Stefania Lostia; Phillip M Tharnish; Mangala Ramesh; Chung K Chu; Robert Jordan; Junxing Shi; Suguna Rachakonda; Kyoichi A Watanabe; Michael J Otto; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2003-01       Impact factor: 5.191

2.  Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome.

Authors:  Q L Choo; G Kuo; A J Weiner; L R Overby; D W Bradley; M Houghton
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

3.  Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection.

Authors:  Fasiha Kanwal; Tuyen Hoang; Jennifer R Kramer; Steven M Asch; Matthew Bidwell Goetz; Angelique Zeringue; Peter Richardson; Hashem B El-Serag
Journal:  Gastroenterology       Date:  2010-12-22       Impact factor: 22.682

4.  Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors.

Authors:  Yili Ding; Haoyun An; Zhi Hong; Jean-Luc Girardet
Journal:  Bioorg Med Chem Lett       Date:  2005-02-01       Impact factor: 2.823

5.  Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.

Authors:  Ramu Rondla; Steven J Coats; Tamara R McBrayer; Jason Grier; Melissa Johns; Phillip M Tharnish; Tony Whitaker; Longhu Zhou; Raymond F Schinazi
Journal:  Antivir Chem Chemother       Date:  2009-10-19

6.  New Merck and Vertex drugs raise standard of care in hepatitis C.

Authors:  Cormac Sheridan
Journal:  Nat Biotechnol       Date:  2011-07-11       Impact factor: 54.908

7.  Pyrrolopyrimidine nucleosides. 3. The total synthesis of toyocamycin, sangivamycin, tubercidin, and related derivatives.

Authors:  R L Tolman; R K Robins; L B Townsend
Journal:  J Am Chem Soc       Date:  1969-04-09       Impact factor: 15.419

8.  Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.

Authors:  Lieven J Stuyver; Stefania Lostia; Marjorie Adams; Judy S Mathew; Balakrishna S Pai; Jason Grier; Phillip M Tharnish; Yongseok Choi; Youhoon Chong; Hyunah Choo; Chung K Chu; Michael J Otto; Raymond F Schinazi
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

9.  Synthesis of certain [6:5:6] linear tricyclic nucleosides as potential antitumor agents.

Authors:  F L Chung; K H Schram; R P Panzica; R A Earl; L L Wotring; L B Townsend
Journal:  J Med Chem       Date:  1980-11       Impact factor: 7.446

Review 10.  Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.

Authors:  Michael J Sofia; Wonsuk Chang; Phillip A Furman; Ralph T Mosley; Bruce S Ross
Journal:  J Med Chem       Date:  2012-01-23       Impact factor: 7.446
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  3 in total

Review 1.  Pyrrolo[2,3-d]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides.

Authors:  Pavla Perlíková; Michal Hocek
Journal:  Med Res Rev       Date:  2017-08-23       Impact factor: 12.944

2.  An Expedient Total Synthesis of Triciribine.

Authors:  Chen Hu; Zhizhong Ruan; Haixin Ding; Yirong Zhou; Qiang Xiao
Journal:  Molecules       Date:  2017-04-17       Impact factor: 4.411

Review 3.  The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold.

Authors:  Mary K Yates; Katherine L Seley-Radtke
Journal:  Antiviral Res       Date:  2018-12-08       Impact factor: 10.103
  3 in total

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