Literature DB >> 15664845

Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors.

Yili Ding1, Haoyun An, Zhi Hong, Jean-Luc Girardet.   

Abstract

Coupling reaction of 2-beta-C-methyl-1,2,3,4-tetra-O-benzoyl-d-ribofuranose with 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine, followed by debromination and debenzoylation, gave the 2'-beta-C-methyl toyocamycin in high yield. Based on this result, a series of 2'-beta-C-methyl-4-substituted toyocamycin and sangivamycin analogues were synthesized for biological screening as potential inhibitors of HCV RNA replication.

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Year:  2005        PMID： 15664845     DOI： 10.1016/j.bmcl.2004.11.019

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis of purine and 7-deazapurine nucleoside analogues of 6-N-(4-Nitrobenzyl)adenosine; inhibition of nucleoside transport and proliferation of cancer cells.

Authors:  Ramanjaneyulu Rayala; Patricia Theard; Heysell Ortiz; Sylvia Yao; James D Young; Jan Balzarini; Morris J Robins; Stanislaw F Wnuk
Journal:  ChemMedChem       Date:  2014-04-30       Impact factor: 3.466

2.  Exploration of 4-aminopyrrolo[2,3-d]pyrimidine as antitubercular agents.

Authors:  Omobolanle Janet Jesumoroti; Richard M Beteck; Audrey Jordaan; Digby F Warner; Lesetja J Legoabe
Journal:  Mol Divers       Date:  2022-05-22       Impact factor: 3.364

3.  Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.

Authors:  Longhu Zhou; Franck Amblard; Hongwang Zhang; Tamara R McBrayer; Mervi A Detorio; Tony Whitaker; Steven J Coats; Raymond F Schinazi
Journal:  Bioorg Med Chem Lett       Date:  2013-03-29       Impact factor: 2.823
  3 in total

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