OBJECTIVES: To evaluate the association between six nondisease-specific problems (problems that cross multiple domains of health) and mortality in middle-aged and older adults. DESIGN: Prospective, observational cohort. SETTING: U.S. population sample. PARTICIPANTS: Participants included 23,669 black and white U.S. adults aged 45 and older enrolled in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. MEASUREMENTS: Nondisease-specific problems included cognitive impairment, depressive symptoms, exhaustion, falls, impaired mobility, and polypharmacy. Age-stratified (<65, 65-74, ≥ 75) hazard ratios for all-cause mortality were calculated for each problem individually and according to number of problems. RESULTS: One or more nondisease-specific problems occurred in 40% of participants younger than 65, 45% of those aged 65 to 74, and 55% of those aged 75 and older. Compared with participants with none of these problems, the multivariable adjusted hazard ratio for all-cause mortality associated with each additional nondisease-specific problem was 1.34 (95% confidence interval (CI) = 1.23-1.46) for participants younger than 65, 1.24 (95% CI = 1.15-1.35) for those aged 65 to 74, and 1.30 (95% CI = 1.21-1.39) for those aged 75 and older. CONCLUSION: Nondisease-specific problems were associated with mortality across a wide age spectrum. Future studies should explore whether treating these problems will improve survival and identify innovative healthcare models to address multiple nondisease-specific problems simultaneously.
OBJECTIVES: To evaluate the association between six nondisease-specific problems (problems that cross multiple domains of health) and mortality in middle-aged and older adults. DESIGN: Prospective, observational cohort. SETTING: U.S. population sample. PARTICIPANTS: Participants included 23,669 black and white U.S. adults aged 45 and older enrolled in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. MEASUREMENTS: Nondisease-specific problems included cognitive impairment, depressive symptoms, exhaustion, falls, impaired mobility, and polypharmacy. Age-stratified (<65, 65-74, ≥ 75) hazard ratios for all-cause mortality were calculated for each problem individually and according to number of problems. RESULTS: One or more nondisease-specific problems occurred in 40% of participants younger than 65, 45% of those aged 65 to 74, and 55% of those aged 75 and older. Compared with participants with none of these problems, the multivariable adjusted hazard ratio for all-cause mortality associated with each additional nondisease-specific problem was 1.34 (95% confidence interval (CI) = 1.23-1.46) for participants younger than 65, 1.24 (95% CI = 1.15-1.35) for those aged 65 to 74, and 1.30 (95% CI = 1.21-1.39) for those aged 75 and older. CONCLUSION: Nondisease-specific problems were associated with mortality across a wide age spectrum. Future studies should explore whether treating these problems will improve survival and identify innovative healthcare models to address multiple nondisease-specific problems simultaneously.
Authors: Christine T Cigolle; Kenneth M Langa; Mohammed U Kabeto; Zhiyi Tian; Caroline S Blaum Journal: Ann Intern Med Date: 2007-08-07 Impact factor: 25.391
Authors: Eric J Lenze; Richard Schulz; Lynn M Martire; Bozena Zdaniuk; Thomas Glass; Willem J Kop; Sharon A Jackson; Charles F Reynolds Journal: J Am Geriatr Soc Date: 2005-04 Impact factor: 5.562
Authors: Virginia J Howard; Mary Cushman; Leavonne Pulley; Camilo R Gomez; Rodney C Go; Ronald J Prineas; Andra Graham; Claudia S Moy; George Howard Journal: Neuroepidemiology Date: 2005-06-29 Impact factor: 3.282
Authors: Kristine E Ensrud; Susan K Ewing; Brent C Taylor; Howard A Fink; Peggy M Cawthon; Katie L Stone; Teresa A Hillier; Jane A Cauley; Marc C Hochberg; Nicolas Rodondi; J Kathleen Tracy; Steven R Cummings Journal: Arch Intern Med Date: 2008-02-25
Authors: Wesley T O'Neal; Waqas T Qureshi; Suzanne E Judd; C Barrett Bowling; Virginia J Howard; George Howard; Elsayed Z Soliman Journal: Am J Cardiol Date: 2015-07-29 Impact factor: 2.778
Authors: Andrei D Javier; Rocio Figueroa; Edward D Siew; Huzaifah Salat; Jennifer Morse; Thomas G Stewart; Rakesh Malhotra; Manisha Jhamb; Jane O Schell; Cesar Y Cardona; Cathy A Maxwell; T Alp Ikizler; Khaled Abdel-Kader Journal: Am J Kidney Dis Date: 2017-02-15 Impact factor: 8.860
Authors: Wesley T O'Neal; Waqas Qureshi; Suzanne E Judd; Stephen P Glasser; Lama Ghazi; LeaVonne Pulley; Virginia J Howard; George Howard; Elsayed Z Soliman Journal: Ann Behav Med Date: 2015-12
Authors: C Barrett Bowling; John N Booth; Orlando M Gutiérrez; Manjula Kurella Tamura; Lei Huang; Meredith Kilgore; Suzanne Judd; David G Warnock; William M McClellan; Richard M Allman; Paul Muntner Journal: Clin J Am Soc Nephrol Date: 2014-10-02 Impact factor: 8.237
Authors: Jessica W Weiss; Robert W Platt; Micah L Thorp; Xiuhai Yang; David H Smith; Amanda Petrik; Elizabeth Eckstrom; Cynthia Morris; Ann M O'Hare; Eric S Johnson Journal: J Am Geriatr Soc Date: 2015-03-04 Impact factor: 5.562
Authors: Genevieve Barlas; Robert L Luben; Samuel R Neal; Nicholas J Wareham; Kay-Tee Khaw; Phyo K Myint Journal: Stroke Date: 2020-03-04 Impact factor: 7.914