Wesley T O'Neal1, Waqas Qureshi2, Suzanne E Judd3, Stephen P Glasser4, Lama Ghazi4, LeaVonne Pulley5, Virginia J Howard6, George Howard3, Elsayed Z Soliman2,7. 1. Department of Internal Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA. woneal@wakehealth.edu. 2. Department of Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, NC, USA. 3. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA. 4. Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. 5. Department of Health Behavior and Health Education, College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA. 6. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA. 7. Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Abstract
BACKGROUND: The association between perceived stress and atrial fibrillation (AF) remains unclear. PURPOSE: The aim of this study was to examine the association between perceived stress and AF. METHODS: A total of 25,530 participants (mean age 65 ± 9.4 years; 54 % women; 41 % blacks) from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were included in this analysis. Logistic regression was used to compute odds ratios (OR) and 95 % confidence intervals (CI) for the association between the short version of the Cohen Perceived Stress Scale and AF. RESULTS: In a multivariable analysis adjusted for demographics, cardiovascular risk factors, and potential confounders, the prevalence of AF was found to increase with higher levels of stress (none: OR = 1.0, referent; low stress: OR = 1.12, 95 % CI = 0.98, 1.27; moderate stress OR = 1.27, 95 % CI = 1.11, 1.47; high stress: OR = 1.60, 95 % CI = 1.39, 1.84). CONCLUSION: Increasing levels of perceived stress are associated with prevalent AF in REGARDS.
BACKGROUND: The association between perceived stress and atrial fibrillation (AF) remains unclear. PURPOSE: The aim of this study was to examine the association between perceived stress and AF. METHODS: A total of 25,530 participants (mean age 65 ± 9.4 years; 54 % women; 41 % blacks) from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were included in this analysis. Logistic regression was used to compute odds ratios (OR) and 95 % confidence intervals (CI) for the association between the short version of the Cohen Perceived Stress Scale and AF. RESULTS: In a multivariable analysis adjusted for demographics, cardiovascular risk factors, and potential confounders, the prevalence of AF was found to increase with higher levels of stress (none: OR = 1.0, referent; low stress: OR = 1.12, 95 % CI = 0.98, 1.27; moderate stress OR = 1.27, 95 % CI = 1.11, 1.47; high stress: OR = 1.60, 95 % CI = 1.39, 1.84). CONCLUSION: Increasing levels of perceived stress are associated with prevalent AF in REGARDS.
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