OBJECTIVE: We compared results from various methods of analysis of diffusion tensor imaging (DTI) data from a single dataset consisting of 10 healthy adolescents. SUBJECTS AND METHODS: All subjects were imaged on a single 3-T MRI system (single-shot echo-planar imaging pulse sequence; b value, 1000 s/mm(2)). We measured fractional anisotropy (FA), apparent diffusion coefficient (ADC), and axial and radial diffusivity values using 64-pixel rectangular regions of interest (ROIs) in the right side, midline, and left side of the central portion of the splenium of the corpus callosum for fixed (i.e., at same sites in all subjects) and targeted (i.e., at sites of highest FA values) locations. We compared results with those obtained using 64-pixel oval ROIs and 100-pixel rectangular ROIs in the same locations. Finally, we compared results from ROI-based methods and from tractography. All comparisons used the Wilcoxon signed rank test and the intraclass correlation of individual values. RESULTS: Compared to tractography, the average of mean ROI-based values was significantly higher for fixed (approximately 14%) and targeted (approximately 39%) FA values and was significantly lower for ADC (approximately 16%) and radial diffusivity (approximately 38%) values. For solely ROI-based comparisons, statistically significant differences were found in the following comparisons: 64- versus 100-pixel ROI, oval versus rectangular ROI, targeted FA left of midline versus mean targeted FA value, and targeted ROI right of midline versus mean targeted FA value. CONCLUSION: Markedly different values were obtained when using either ROI- or tractography-based techniques or ROI analysis techniques that differ only relatively slightly.
OBJECTIVE: We compared results from various methods of analysis of diffusion tensor imaging (DTI) data from a single dataset consisting of 10 healthy adolescents. SUBJECTS AND METHODS: All subjects were imaged on a single 3-T MRI system (single-shot echo-planar imaging pulse sequence; b value, 1000 s/mm(2)). We measured fractional anisotropy (FA), apparent diffusion coefficient (ADC), and axial and radial diffusivity values using 64-pixel rectangular regions of interest (ROIs) in the right side, midline, and left side of the central portion of the splenium of the corpus callosum for fixed (i.e., at same sites in all subjects) and targeted (i.e., at sites of highest FA values) locations. We compared results with those obtained using 64-pixel oval ROIs and 100-pixel rectangular ROIs in the same locations. Finally, we compared results from ROI-based methods and from tractography. All comparisons used the Wilcoxon signed rank test and the intraclass correlation of individual values. RESULTS: Compared to tractography, the average of mean ROI-based values was significantly higher for fixed (approximately 14%) and targeted (approximately 39%) FA values and was significantly lower for ADC (approximately 16%) and radial diffusivity (approximately 38%) values. For solely ROI-based comparisons, statistically significant differences were found in the following comparisons: 64- versus 100-pixel ROI, oval versus rectangular ROI, targeted FA left of midline versus mean targeted FA value, and targeted ROI right of midline versus mean targeted FA value. CONCLUSION: Markedly different values were obtained when using either ROI- or tractography-based techniques or ROI analysis techniques that differ only relatively slightly.
Authors: Hao Huang; Jiangyang Zhang; Hangyi Jiang; Setsu Wakana; Lidia Poetscher; Michael I Miller; Peter C M van Zijl; Argye E Hillis; Robert Wytik; Susumu Mori Journal: Neuroimage Date: 2005-05-15 Impact factor: 6.556
Authors: V J Wedeen; R P Wang; J D Schmahmann; T Benner; W Y I Tseng; G Dai; D N Pandya; P Hagmann; H D'Arceuil; A J de Crespigny Journal: Neuroimage Date: 2008-04-08 Impact factor: 6.556
Authors: J H Gilmore; W Lin; I Corouge; Y S K Vetsa; J K Smith; C Kang; H Gu; R M Hamer; J A Lieberman; G Gerig Journal: AJNR Am J Neuroradiol Date: 2007-10 Impact factor: 3.825
Authors: Won-Jin Moon; James M Provenzale; Basar Sarikaya; Yon Kwon Ihn; John Morlese; Steven Chen; Michael D DeBellis Journal: AJR Am J Roentgenol Date: 2011-09 Impact factor: 3.959
Authors: Maria Giulia Preti; Maria Marcella Laganà; Francesca Baglio; Ludovica Griffanti; Raffaello Nemni; Pietro Cecconi; Giuseppe Baselli Journal: Conf Proc IEEE Eng Med Biol Soc Date: 2011
Authors: Udit Singhania; Balakrushna Tripathy; Mohammad Kamrul Hasan; Noble C Anumbe; Dabiah Alboaneen; Fatima Rayan Awad Ahmed; Thowiba E Ahmed; Manasik M Mohamed Nour Journal: Front Public Health Date: 2021-10-11