BACKGROUND: How different Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifications of chronic obstructive pulmonary disease (COPD) predict mortality is unclear. OBJECTIVE: To examine the association of spirometric GOLD grades and the new ABCD groups with mortality, and to compare their informativeness in relation to mortality. METHODS: We studied 1540 people with post-bronchodilator COPD who participated in the Norwegian Nord-Trøndelag Health Study 1995-1997 and were followed up on all-cause mortality until May 2012. The associations of spirometric GOLD grades and ABCD groups with mortality were estimated by sex specific adjusted HRs from Cox regression and standardised mortality ratios. To assess the informativeness of spirometric GOLD grades and ABCD groups at predicting mortality we used the difference in twice the log-likelihood of a Cox regression model with and without each COPD classification. RESULTS: The distribution of participants was 28% in GOLD 1, 57% in GOLD 2, 13% in GOLD 3 and 2% in GOLD 4, in contrast to 61% in group A, 18% in group B, 12% in group C and 10% in group D. During a median of 14.6 years of follow-up, 837 people (54%) died. Mortality increased gradually from GOLD 1 to 4, while it was generally similar in groups A and B, and in groups C and D. Spirometric GOLD grades were substantially more informative than ABCD groups at predicting mortality. CONCLUSIONS: Spirometric GOLD grades predicted mortality better than the new ABCD groups among people with COPD from a Norwegian general population.
BACKGROUND: How different Global Initiative for Chronic Obstructive Lung Disease (GOLD) classifications of chronic obstructive pulmonary disease (COPD) predict mortality is unclear. OBJECTIVE: To examine the association of spirometric GOLD grades and the new ABCD groups with mortality, and to compare their informativeness in relation to mortality. METHODS: We studied 1540 people with post-bronchodilator COPD who participated in the Norwegian Nord-Trøndelag Health Study 1995-1997 and were followed up on all-cause mortality until May 2012. The associations of spirometric GOLD grades and ABCD groups with mortality were estimated by sex specific adjusted HRs from Cox regression and standardised mortality ratios. To assess the informativeness of spirometric GOLD grades and ABCD groups at predicting mortality we used the difference in twice the log-likelihood of a Cox regression model with and without each COPD classification. RESULTS: The distribution of participants was 28% in GOLD 1, 57% in GOLD 2, 13% in GOLD 3 and 2% in GOLD 4, in contrast to 61% in group A, 18% in group B, 12% in group C and 10% in group D. During a median of 14.6 years of follow-up, 837 people (54%) died. Mortality increased gradually from GOLD 1 to 4, while it was generally similar in groups A and B, and in groups C and D. Spirometric GOLD grades were substantially more informative than ABCD groups at predicting mortality. CONCLUSIONS: Spirometric GOLD grades predicted mortality better than the new ABCD groups among people with COPD from a Norwegian general population.
Authors: Sankar D Navaneethan; Jesse D Schold; Haiquan Huang; Georges Nakhoul; Stacey E Jolly; Susana Arrigain; Raed A Dweik; Joseph V Nally Journal: Am J Nephrol Date: 2016-02-19 Impact factor: 3.754
Authors: Harris Majeed; Hong Zhu; Sarah A Williams; Heidi A Hamann; Vijaya Subbu Natchimuthu; Jessica Lee; Noel O Santini; Travis Browning; Tanushree Prasad; Joyce O Adesina; Minh Do; David Balis; Juana Gamarra de Willams; Ellen Kitchell; David H Johnson; Simon J Craddock Lee; David E Gerber Journal: Clin Lung Cancer Date: 2022-04-29 Impact factor: 4.840
Authors: Esther I Metting; Roland A Riemersma; Janwillem H Kocks; Margriet G Piersma-Wichers; Robbert Sanderman; Thys van der Molen Journal: NPJ Prim Care Respir Med Date: 2015-01-08 Impact factor: 2.871
Authors: Ciro Casanova; Jose M Marin; Cristina Martinez-Gonzalez; Pilar de Lucas-Ramos; Isabel Mir-Viladrich; Borja Cosio; German Peces-Barba; Miryam Calle-Rubio; Ingrid Solanes-García; Ramón Agüero; Alfredo de Diego-Damia; Nuria Feu-Collado; Inmaculada Alfageme; Rosa Irigaray; Eva Balcells; Antonia Llunell; Juan Bautista Galdiz; Margarita Marín; Juan José Soler-Cataluña; Jose Luis Lopez-Campos; Joan B Soriano; Juan P de-Torres Journal: Respir Res Date: 2014-01-13