Literature DB >> 23597559

Sirt4: the glutamine gatekeeper.

Pablo J Fernandez-Marcos1, Manuel Serrano.   

Abstract

Little is known about how DNA damage and metabolism are interconnected. In this issue of Cancer Cell, Jeong and colleagues report that an important component of the DNA damage response is the SIRT4-mediated blockade of glutamine catabolism. Failure to shut down glutamine consumption results in unscheduled proliferation, genomic instability, and cancer.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Year:  2013        PMID： 23597559      PMCID： PMC4851233          DOI： 10.1016/j.ccr.2013.04.003

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  Genotoxic exposure is associated with alterations in glucose uptake and metabolism.

Authors:  Rixin Zhou; Matthew G Vander Heiden; Charles M Rudin
Journal:  Cancer Res       Date:  2002-06-15       Impact factor: 12.701

2.  TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

Authors:  Karim Bensaad; Atsushi Tsuruta; Mary A Selak; M Nieves Calvo Vidal; Katsunori Nakano; Ramon Bartrons; Eyal Gottlieb; Karen H Vousden
Journal:  Cell       Date:  2006-07-14       Impact factor: 41.582

3.  Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.

Authors:  Jian-Bin Wang; Jon W Erickson; Reina Fuji; Sekar Ramachandran; Ping Gao; Ramani Dinavahi; Kristin F Wilson; Andre L B Ambrosio; Sandra M G Dias; Chi V Dang; Richard A Cerione
Journal:  Cancer Cell       Date:  2010-09-14       Impact factor: 31.743

4.  SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

Authors:  Marcia C Haigis; Raul Mostoslavsky; Kevin M Haigis; Kamau Fahie; Danos C Christodoulou; Andrew J Murphy; David M Valenzuela; George D Yancopoulos; Margaret Karow; Gil Blander; Cynthia Wolberger; Tomas A Prolla; Richard Weindruch; Frederick W Alt; Leonard Guarente
Journal:  Cell       Date:  2006-09-08       Impact factor: 41.582

Review 5.  The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.

Authors:  Ralph J DeBerardinis; Julian J Lum; Georgia Hatzivassiliou; Craig B Thompson
Journal:  Cell Metab       Date:  2008-01       Impact factor: 27.287

6.  SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.

Authors:  Seung Min Jeong; Cuiying Xiao; Lydia W S Finley; Tyler Lahusen; Amanda L Souza; Kerry Pierce; Ying-Hua Li; Xiaoxu Wang; Gaëlle Laurent; Natalie J German; Xiaoling Xu; Cuiling Li; Rui-Hong Wang; Jaewon Lee; Alfredo Csibi; Richard Cerione; John Blenis; Clary B Clish; Alec Kimmelman; Chu-Xia Deng; Marcia C Haigis
Journal:  Cancer Cell       Date:  2013-04-04       Impact factor: 31.743

Review 7.  From sirtuin biology to human diseases: an update.

Authors:  Carlos Sebastián; F Kyle Satterstrom; Marcia C Haigis; Raul Mostoslavsky
Journal:  J Biol Chem       Date:  2012-10-18       Impact factor: 5.157

8.  The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.

Authors:  Carles Cantó; Riekelt H Houtkooper; Eija Pirinen; Dou Y Youn; Maaike H Oosterveer; Yana Cen; Pablo J Fernandez-Marcos; Hiroyasu Yamamoto; Pénélope A Andreux; Philippe Cettour-Rose; Karl Gademann; Chris Rinsch; Kristina Schoonjans; Anthony A Sauve; Johan Auwerx
Journal:  Cell Metab       Date:  2012-06-06       Impact factor: 27.287

9.  ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.

Authors:  Claudia Cosentino; Domenico Grieco; Vincenzo Costanzo
Journal:  EMBO J       Date:  2010-12-14       Impact factor: 11.598

10.  Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Authors:  Richard Possemato; Kevin M Marks; Yoav D Shaul; Michael E Pacold; Dohoon Kim; Kıvanç Birsoy; Shalini Sethumadhavan; Hin-Koon Woo; Hyun G Jang; Abhishek K Jha; Walter W Chen; Francesca G Barrett; Nicolas Stransky; Zhi-Yang Tsun; Glenn S Cowley; Jordi Barretina; Nada Y Kalaany; Peggy P Hsu; Kathleen Ottina; Albert M Chan; Bingbing Yuan; Levi A Garraway; David E Root; Mari Mino-Kenudson; Elena F Brachtel; Edward M Driggers; David M Sabatini
Journal:  Nature       Date:  2011-08-18       Impact factor: 49.962
  10 in total
  14 in total

Review 1.  The role of FAK in tumor metabolism and therapy.

Authors:  Jianliang Zhang; Steven N Hochwald
Journal:  Pharmacol Ther       Date:  2013-12-09       Impact factor: 12.310

Review 2.  Mitochondrial Sirtuins in Parkinson's Disease.

Authors:  Ling He; Jihong Wang; Yazhi Yang; Jian Li; Huaijun Tu
Journal:  Neurochem Res       Date:  2022-02-26       Impact factor: 3.996

Review 3.  Glutamine at focus: versatile roles in cancer.

Authors:  Humberto De Vitto; Juan Pérez-Valencia; James A Radosevich
Journal:  Tumour Biol       Date:  2015-12-24

4.  Anabolic SIRT4 Exerts Retrograde Control over TORC1 Signaling by Glutamine Sparing in the Mitochondria.

Authors:  Eisha Shaw; Manasi Talwadekar; Zeenat Rashida; Nitya Mohan; Aishwarya Acharya; Subhash Khatri; Sunil Laxman; Ullas Kolthur-Seetharam
Journal:  Mol Cell Biol       Date:  2020-01-03       Impact factor: 4.272

Review 5.  Oncogenes and tumor suppressors regulate glutamine metabolism in cancer cells.

Authors:  Min Hyun Kim; Hyeyoung Kim
Journal:  J Cancer Prev       Date:  2013-09

Review 6.  Sirtuins in metabolism, DNA repair and cancer.

Authors:  Zhen Mei; Xian Zhang; Jiarong Yi; Junjie Huang; Jian He; Yongguang Tao
Journal:  J Exp Clin Cancer Res       Date:  2016-12-05

7.  Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage.

Authors:  Yumei Wang; Yinmou Guo; Jianzhi Gao; Xiangdong Yuan
Journal:  Cancer Manag Res       Date:  2018-11-09       Impact factor: 3.989

Review 8.  Advances of Molecular Markers and Their Application for Body Variables and Carcass Traits in Qinchuan Cattle.

Authors:  Sayed Haidar Abbas Raza; Rajwali Khan; Sameh A Abdelnour; Mohamed E Abd El-Hack; Asmaa F Khafaga; Ayman Taha; Husein Ohran; Chugang Mei; Nicola M Schreurs; Linsen Zan
Journal:  Genes (Basel)       Date:  2019-09-17       Impact factor: 4.096

9.  VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway.

Authors:  Ying Tong; Jinyan Kai; Shuo Wang; Yiwen Yu; Suhong Xie; Hui Zheng; Yanchun Wang; Yixuan Liu; Keyu Zhu; Xiaolin Guan; Lin Guo; Renquan Lu
Journal:  Cell Death Dis       Date:  2021-06-16       Impact factor: 8.469

10.  Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer.

Authors:  Qingyu Shi; Tong Liu; Xianyu Zhang; Jingshu Geng; Xiaohui He; Ming Nu; Da Pang
Journal:  Oncol Lett       Date:  2016-08-16       Impact factor: 2.967
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