| Literature DB >> 18177721 |
Ralph J DeBerardinis1, Julian J Lum, Georgia Hatzivassiliou, Craig B Thompson.
Abstract
Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis.Entities:
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Year: 2008 PMID： 18177721 DOI： 10.1016/j.cmet.2007.10.002
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287