Literature DB >> 23086954

From sirtuin biology to human diseases: an update.

Carlos Sebastián1, F Kyle Satterstrom, Marcia C Haigis, Raul Mostoslavsky.   

Abstract

Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of NAD(+)-dependent enzymes that have been connected to a steadily growing set of biological processes. In addition to regulating aging, sirtuins play key roles in the maintenance of organismal metabolic homeostasis. These enzymes also have primarily protective functions in the development of many age-related diseases, including cancer, neurodegeneration, and cardiovascular disease. In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas.

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Year:  2012        PMID： 23086954      PMCID： PMC3522245          DOI： 10.1074/jbc.R112.402768

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  105 in total

1.  Ageing: Sorting out the sirtuins.

Authors:  David B Lombard; Richard A Miller
Journal:  Nature       Date:  2012-03-07       Impact factor: 49.962

Review 2.  Ageing and hearing loss.

Authors:  X Z Liu; D Yan
Journal:  J Pathol       Date:  2007-01       Impact factor: 7.996

3.  Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors:  Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

4.  SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.

Authors:  Hyun-Seok Kim; Athanassios Vassilopoulos; Rui-Hong Wang; Tyler Lahusen; Zhen Xiao; Xiaoling Xu; Cuiling Li; Timothy D Veenstra; Bing Li; Hongtao Yu; Junfang Ji; Xin Wei Wang; Seong-Hoon Park; Yong I Cha; David Gius; Chu-Xia Deng
Journal:  Cancer Cell       Date:  2011-10-18       Impact factor: 31.743

5.  Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6.

Authors:  Yi Cai; Shan-Shan Yu; Shao-Rui Chen; Rong-Biao Pi; Si Gao; Hong Li; Jian-Tao Ye; Pei-Qing Liu
Journal:  FEBS Lett       Date:  2012-02-20       Impact factor: 4.124

6.  Roles of SIRT1 in the acute and restorative phases following induction of inflammation.

Authors:  Zhiyong Zhang; Stephen F Lowry; Leonard Guarente; Beatrice Haimovich
Journal:  J Biol Chem       Date:  2010-10-21       Impact factor: 5.157

7.  SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310.

Authors:  Karin M Rothgiesser; Süheda Erener; Susanne Waibel; Bernhard Lüscher; Michael O Hottiger
Journal:  J Cell Sci       Date:  2010-11-16       Impact factor: 5.285

8.  The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors:  M Kaeberlein; M McVey; L Guarente
Journal:  Genes Dev       Date:  1999-10-01       Impact factor: 11.361

9.  SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Authors:  Tadahiro Shimazu; Matthew D Hirschey; Lan Hua; Kristin E Dittenhafer-Reed; Bjoern Schwer; David B Lombard; Yu Li; Jakob Bunkenborg; Frederick W Alt; John M Denu; Matthew P Jacobson; Eric Verdin
Journal:  Cell Metab       Date:  2010-12-01       Impact factor: 27.287

10.  Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway.

Authors:  Vinodkumar B Pillai; Nagalingam R Sundaresan; Gene Kim; Madhu Gupta; Senthilkumar B Rajamohan; Jyothish B Pillai; Sadhana Samant; P V Ravindra; Ayman Isbatan; Mahesh P Gupta
Journal:  J Biol Chem       Date:  2009-11-24       Impact factor: 5.157
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  93 in total

1.  A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells.

Authors:  Turki Y Alhazzazi; Pachiyappan Kamarajan; Yanli Xu; Teng Ai; Liqiang Chen; Eric Verdin; Yvonne L Kapila
Journal:  Anticancer Res       Date:  2016-01       Impact factor: 2.480

2.  The diversity of histone versus nonhistone sirtuin substrates.

Authors:  Paloma Martínez-Redondo; Alejandro Vaquero
Journal:  Genes Cancer       Date:  2013-03

3.  SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity.

Authors:  Kosuke Funato; Tomoatsu Hayashi; Kanae Echizen; Lumi Negishi; Naomi Shimizu; Ryo Koyama-Nasu; Yukiko Nasu-Nishimura; Yasuyuki Morishita; Viviane Tabar; Tomoki Todo; Yasushi Ino; Akitake Mukasa; Nobuhito Saito; Tetsu Akiyama
Journal:  EMBO Rep       Date:  2018-09-13       Impact factor: 8.807

4.  Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice.

Authors:  Geng Tian; Jinko Sawashita; Hiroshi Kubo; Shin-ya Nishio; Shigenari Hashimoto; Nobuyoshi Suzuki; Hidekane Yoshimura; Mineko Tsuruoka; Yaoyong Wang; Yingye Liu; Hongming Luo; Zhe Xu; Masayuki Mori; Mitsuaki Kitano; Kazunori Hosoe; Toshio Takeda; Shin-ichi Usami; Keiichi Higuchi
Journal:  Antioxid Redox Signal       Date:  2013-12-14       Impact factor: 8.401

5.  High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.

Authors:  Qian Geng; Haoyu Peng; Fengsheng Chen; Rongcheng Luo; Rong Li
Journal:  Int J Clin Exp Pathol       Date:  2015-02-01

Review 6.  Sirtuins and the Metabolic Hurdles in Cancer.

Authors:  Natalie J German; Marcia C Haigis
Journal:  Curr Biol       Date:  2015-06-29       Impact factor: 10.834

7.  Biochemical characterization of sirtuin 6 in the brain and its involvement in oxidative stress response.

Authors:  Alessio Cardinale; Maria Chiara de Stefano; Cristiana Mollinari; Mauro Racaniello; Enrico Garaci; Daniela Merlo
Journal:  Neurochem Res       Date:  2014-11-01       Impact factor: 3.996

Review 8.  Current understanding and future perspectives of the roles of sirtuins in the reprogramming and differentiation of pluripotent stem cells.

Authors:  Yi-Chao Hsu; Yu-Ting Wu; Chia-Ling Tsai; Yau-Huei Wei
Journal:  Exp Biol Med (Maywood)       Date:  2018-03

9.  Sirtuin 1 inhibits TNF-α-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation.

Authors:  Shu Yan; Lujie Miao; Yahua Lu; Liangzhi Wang
Journal:  Mol Cell Biochem       Date:  2018-11-20       Impact factor: 3.396

10.  Is SIRT2 required for necroptosis?

Authors:  Kim Newton; Joanne M Hildebrand; Zhirong Shen; Diego Rodriguez; Silvia Alvarez-Diaz; Sean Petersen; Saumil Shah; Debra L Dugger; Chunzi Huang; Johan Auwerx; Peter Vandenabeele; Douglas R Green; Avi Ashkenazi; Vishva M Dixit; William J Kaiser; Andreas Strasser; Alexei Degterev; John Silke
Journal:  Nature       Date:  2014-02-27       Impact factor: 49.962
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