Literature DB >> 23595991

Macro histone variants are critical for the differentiation of human pluripotent cells.

María J Barrero1, Borja Sese, Mercè Martí, Juan Carlos Izpisua Belmonte.   

Abstract

We have previously shown that macro histone variants (macroH2A) are expressed at low levels in stem cells and are up-regulated during differentiation. Here we show that the knockdown of macro histone variants impaired the in vitro and in vivo differentiation of human pluripotent cells, likely through defects in the silencing of pluripotency-related genes. ChIP experiments showed that during differentiation macro histone variants are recruited to the regulatory regions of pluripotency and developmental genes marked with H3K27me3 contributing to the silencing of these genes.

Entities:  

Keywords:  Chromatin; Differentiation; Induced Pluripotent Stem (iPS) Cell; Macro Histone Variants; Pluripotency; Stem Cells

Mesh：

Substances：

Year:  2013        PMID： 23595991      PMCID： PMC3668766          DOI： 10.1074/jbc.M113.466144

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  31 in total

1.  The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling.

Authors:  Dimitar Angelov; Annie Molla; Pierre-Yves Perche; Fabienne Hans; Jacques Côté; Saadi Khochbin; Philippe Bouvet; Stefan Dimitrov
Journal:  Mol Cell       Date:  2003-04       Impact factor: 17.970

Review 2.  Multiple facets of the unique histone variant macroH2A: from genomics to cell biology.

Authors:  Matthew J Gamble; W Lee Kraus
Journal:  Cell Cycle       Date:  2010-07-01       Impact factor: 4.534

3.  Efficient differentiation of human embryonic stem cells to definitive endoderm.

Authors:  Kevin A D'Amour; Alan D Agulnick; Susan Eliazer; Olivia G Kelly; Evert Kroon; Emmanuel E Baetge
Journal:  Nat Biotechnol       Date:  2005-10-28       Impact factor: 54.908

Review 4.  Embryonic stem cell differentiation: emergence of a new era in biology and medicine.

Authors:  Gordon Keller
Journal:  Genes Dev       Date:  2005-05-15       Impact factor: 11.361

5.  The histone variant macroH2A1 marks repressed autosomal chromatin, but protects a subset of its target genes from silencing.

Authors:  Matthew J Gamble; Kristine M Frizzell; Christine Yang; Raga Krishnakumar; W Lee Kraus
Journal:  Genes Dev       Date:  2009-12-15       Impact factor: 11.361

6.  The histone variant macroH2A is an epigenetic regulator of key developmental genes.

Authors:  Marcus Buschbeck; Iris Uribesalgo; Indra Wibowo; Pau Rué; David Martin; Arantxa Gutierrez; Lluís Morey; Roderic Guigó; Hernán López-Schier; Luciano Di Croce
Journal:  Nat Struct Mol Biol       Date:  2009-09-06       Impact factor: 15.369

7.  MacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells.

Authors:  Catherine Creppe; Peggy Janich; Neus Cantariño; Marc Noguera; Vanesa Valero; Eva Musulén; Julien Douet; Melanija Posavec; Juan Martín-Caballero; Lauro Sumoy; Luciano Di Croce; Salvador A Benitah; Marcus Buschbeck
Journal:  Mol Cell Biol       Date:  2012-02-13       Impact factor: 4.272

8.  Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts.

Authors:  A Raya; I Rodríguez-Pizà; B Arán; A Consiglio; P N Barri; A Veiga; J C Izpisúa Belmonte
Journal:  Cold Spring Harb Symp Quant Biol       Date:  2008-11-21

9.  Histone variant macroH2A confers resistance to nuclear reprogramming.

Authors:  Vincent Pasque; Astrid Gillich; Nigel Garrett; John B Gurdon
Journal:  EMBO J       Date:  2011-05-06       Impact factor: 11.598

10.  Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency.

Authors:  Vincent Pasque; Aliaksandra Radzisheuskaya; Astrid Gillich; Richard P Halley-Stott; Maryna Panamarova; Magdalena Zernicka-Goetz; M Azim Surani; José C R Silva
Journal:  J Cell Sci       Date:  2012-10-17       Impact factor: 5.285
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  20 in total

Review 1.  Variants of core histones and their roles in cell fate decisions, development and cancer.

Authors:  Marcus Buschbeck; Sandra B Hake
Journal:  Nat Rev Mol Cell Biol       Date:  2017-02-01       Impact factor: 94.444

2.  MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms.

Authors:  Marek Kozlowski; David Corujo; Michael Hothorn; Iva Guberovic; Imke K Mandemaker; Charlotte Blessing; Judith Sporn; Arturo Gutierrez-Triana; Rebecca Smith; Thomas Portmann; Mathias Treier; Klaus Scheffzek; Sebastien Huet; Gyula Timinszky; Marcus Buschbeck; Andreas G Ladurner
Journal:  EMBO Rep       Date:  2018-09-03       Impact factor: 8.807

Review 3.  The roles of histone variants in fine-tuning chromatin organization and function.

Authors:  Sara Martire; Laura A Banaszynski
Journal:  Nat Rev Mol Cell Biol       Date:  2020-07-14       Impact factor: 94.444

4.  The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1.

Authors:  Kristine M Hussey; Hongshan Chen; Christine Yang; Eugene Park; Nasun Hah; Hediye Erdjument-Bromage; Paul Tempst; Matthew J Gamble; W Lee Kraus
Journal:  Mol Cell Biol       Date:  2014-04-21       Impact factor: 4.272

5.  The characterization of macroH2A beyond vertebrates supports an ancestral origin and conserved role for histone variants in chromatin.

Authors:  Ciro Rivera-Casas; Rodrigo Gonzalez-Romero; Manjinder S Cheema; Juan Ausió; José M Eirín-López
Journal:  Epigenetics       Date:  2016-04-15       Impact factor: 4.528

6.  Nuclear deformation guides chromatin reorganization in cardiac development and disease.

Authors:  Benjamin Seelbinder; Soham Ghosh; Stephanie E Schneider; Adrienne K Scott; Alycia G Berman; Craig J Goergen; Kenneth B Margulies; Kenneth C Bedi; Eduard Casas; Alison R Swearingen; Justin Brumbaugh; Sarah Calve; Corey P Neu
Journal:  Nat Biomed Eng       Date:  2021-12-02       Impact factor: 29.234

7.  Mice without macroH2A histone variants.

Authors:  John R Pehrson; Lakshmi N Changolkar; Carl Costanzi; N Adrian Leu
Journal:  Mol Cell Biol       Date:  2014-10-13       Impact factor: 4.272

Review 8.  Human Induced Pluripotent Stem Cells: From Cell Origin, Genomic Stability, and Epigenetic Memory to Translational Medicine.

Authors:  Mareike S Poetsch; Anna Strano; Kaomei Guan
Journal:  Stem Cells       Date:  2022-06-22       Impact factor: 5.845

Review 9.  Epigenetic mechanisms of induced pluripotency.

Authors:  Marta Gładych; Anastazja Andrzejewska; Urszula Oleksiewicz; Marcos R H Estécio
Journal:  Contemp Oncol (Pozn)       Date:  2015

10.  Epigenetic changes during hematopoietic cell granulocytic differentiation--comparative analysis of primary CD34+ cells, KG1 myeloid cells and mature neutrophils.

Authors:  Rūta Navakauskienė; Veronika V Borutinskaitė; Gražina Treigytė; Jūratė Savickienė; Dalius Matuzevičius; Dalius Navakauskas; Karl-Eric Magnusson
Journal:  BMC Cell Biol       Date:  2014-01-20       Impact factor: 4.241
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