Literature DB >> 23592319

Accurate automated apnea analysis in preterm infants.

Brooke D Vergales1, Alix O Paget-Brown1, Hoshik Lee2, Lauren E Guin3, Terri J Smoot3, Craig G Rusin3, Matthew T Clark4, John B Delos2, Karen D Fairchild1, Douglas E Lake3, Randall Moorman3, John Kattwinkel1.   

Abstract

OBJECTIVE: In 2006 the apnea of prematurity (AOP) consensus group identified inaccurate counting of apnea episodes as a major barrier to progress in AOP research. We compare nursing records of AOP to events detected by a clinically validated computer algorithm that detects apnea from standard bedside monitors. STUDY
DESIGN: Waveform, vital sign, and alarm data were collected continuously from all very low-birth-weight infants admitted over a 25-month period, analyzed for central apnea, bradycardia, and desaturation (ABD) events, and compared with nursing documentation collected from charts. Our algorithm defined apnea as > 10 seconds if accompanied by bradycardia and desaturation.
RESULTS: Of the 3,019 nurse-recorded events, only 68% had any algorithm-detected ABD event. Of the 5,275 algorithm-detected prolonged apnea events > 30 seconds, only 26% had nurse-recorded documentation within 1 hour. Monitor alarms sounded in only 74% of events of algorithm-detected prolonged apnea events > 10 seconds. There were 8,190,418 monitor alarms of any description throughout the neonatal intensive care unit during the 747 days analyzed, or one alarm every 2 to 3 minutes per nurse.
CONCLUSION: An automated computer algorithm for continuous ABD quantitation is a far more reliable tool than the medical record to address the important research questions identified by the 2006 AOP consensus group. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

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Year:  2013        PMID: 23592319      PMCID: PMC5321050          DOI: 10.1055/s-0033-1343769

Source DB:  PubMed          Journal:  Am J Perinatol        ISSN: 0735-1631            Impact factor:   1.862


  22 in total

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Authors:  Jing Zhao; Fernando Gonzalez; Dezhi Mu
Journal:  Eur J Pediatr       Date:  2011-02-08       Impact factor: 3.183

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  22 in total

1.  Impact of Caffeine Boluses and Caffeine Discontinuation on Apnea and Hypoxemia in Preterm Infants.

Authors:  Christa R Tabacaru; Suk Young Jang; Manisha Patel; Faranek Davalian; Santina Zanelli; Karen D Fairchild
Journal:  J Caffeine Res       Date:  2017-09-01

2.  Stochastic modeling of central apnea events in preterm infants.

Authors:  Matthew T Clark; John B Delos; Douglas E Lake; Hoshik Lee; Karen D Fairchild; John Kattwinkel; J Randall Moorman
Journal:  Physiol Meas       Date:  2016-03-10       Impact factor: 2.833

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Authors:  Sanjiv B Amin; Hongyue Wang
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Authors:  Mary A Mohr; Brooke D Vergales; Hoshik Lee; Matthew T Clark; Douglas E Lake; Anne C Mennen; John Kattwinkel; Robert A Sinkin; J Randall Moorman; Karen D Fairchild; John B Delos
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Review 6.  Vital signs as physiomarkers of neonatal sepsis.

Authors:  Brynne A Sullivan; Karen D Fairchild
Journal:  Pediatr Res       Date:  2021-09-07       Impact factor: 3.756

7.  Early bradycardia detection and therapeutic interventions in preterm infant monitoring.

Authors:  Matthieu Doyen; Alfredo I Hernández; Cyril Flamant; Antoine Defontaine; Géraldine Favrais; Miguel Altuve; Bruno Laviolle; Alain Beuchée; Guy Carrault; Patrick Pladys
Journal:  Sci Rep       Date:  2021-05-18       Impact factor: 4.379

8.  Abrupt changes in pentobarbital sensitivity in preBötzinger complex region, hypoglossal motor nucleus, nucleus tractus solitarius, and cortex during rat transitional period (P10-P15).

Authors:  Sara M F Turner; Stephen M Johnson
Journal:  Respir Physiol Neurobiol       Date:  2014-12-27       Impact factor: 2.821

9.  Predicting apneic events in preterm infants using cardio-respiratory and movement features.

Authors:  Ian Zuzarte; Dagmar Sternad; David Paydarfar
Journal:  Comput Methods Programs Biomed       Date:  2021-07-30       Impact factor: 7.027

10.  Oxygen Saturation in Infants With Retinopathy of Prematurity-Reply.

Authors:  Ankita Shukla; Jonathan E Sears
Journal:  JAMA Ophthalmol       Date:  2019-09-01       Impact factor: 8.253

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