| Literature DB >> 23587442 |
Yael Spector1, Eddie Fridman, Shai Rosenwald, Sofia Zilber, Yajue Huang, Iris Barshack, Orit Zion, Heather Mitchell, Mats Sanden, Eti Meiri.
Abstract
Renal cancers account for more than 3% of adult malignancies and cause more than 13,000 deaths per year in the US alone. The four most common types of kidney tumors include the malignant renal cell carcinomas; clear cell, papillary, chromophobe and the benign oncocytoma. These histological subtypes vary in their clinical course and prognosis, and different clinical strategies have been developed for their management. In some kidney tumor cases it can be very difficult for the pathologist to distinguish between tumor types on the basis of morphology and immunohistochemistry (IHC). In this publication we present the development and validation of a microRNA-based assay for classifying primary kidney tumors. The assay, which classifies the four main kidney tumor types, was developed based on the expression of a set of 24 microRNAs. A validation set of 201 independent samples was classified using the assay and analyzed blindly. The assay produced results for 92% of the samples with an accuracy of 95%.Entities:
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Year: 2013 PMID： 23587442 PMCID： PMC5528479 DOI： 10.1016/j.molonc.2013.03.002
Source DB: PubMed Journal: Mol Oncol ISSN： 1574-7891 Impact factor: 6.603