Literature DB >> 3257575

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

S W Lee1, A P Tsou, H Chan, J Thomas, K Petrie, E M Eugui, A C Allison.   

Abstract

Transcription of the interleukin 1 beta (IL-1 beta) gene was studied by mRNA hybridization with a cDNA probe in the human promonocytic cell line U-937. Phorbol ester and lipopolysaccharide increased the steady-state level of IL-1 beta mRNA. Glucocorticoids markedly decreased IL-1 beta mRNA levels by two mechanisms. Transcription of the IL-1 gene was inhibited, as shown by in vitro transcription assays with nuclei isolated from glucocorticoid-treated cells. Moreover, kinetic analyses and pulse-labeling of mRNAs showed that glucocorticoids selectively decrease the stability of IL-1 beta mRNA, without affecting the stability of beta-actin and FOS mRNAs. Inhibition of the formation and effects IL-1 is a mechanism by which glucocorticoids can exert antiinflammatory and immunosuppressive effects.

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Year:  1988        PMID： 3257575      PMCID： PMC279735          DOI： 10.1073/pnas.85.4.1204

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  41 in total

1.  Selective reduction of proadrenocorticotropin/endorphin proteins and messenger ribonucleic acid activity in mouse pituitary tumor cells by glucocorticoids.

Authors:  J L Roberts; M L Budarf; J D Baxter; E Herbert
Journal:  Biochemistry       Date:  1979-10-30       Impact factor: 3.162

2.  Glucocorticoids stimulate ribonucleic acid degradation in isolated rat thymic lymphocytes in vitro.

Authors:  J A Cidlowski
Journal:  Endocrinology       Date:  1982-07       Impact factor: 4.736

3.  Cytoplasmic dot hybridization. Simple analysis of relative mRNA levels in multiple small cell or tissue samples.

Authors:  B A White; F C Bancroft
Journal:  J Biol Chem       Date:  1982-08-10       Impact factor: 5.157

4.  Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct.

Authors:  G S McKnight; R D Palmiter
Journal:  J Biol Chem       Date:  1979-09-25       Impact factor: 5.157

5.  Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure.

Authors:  F C Kafatos; C W Jones; A Efstratiadis
Journal:  Nucleic Acids Res       Date:  1979-11-24       Impact factor: 16.971

6.  Establishment and characterization of a human histiocytic lymphoma cell line (U-937).

Authors:  C Sundström; K Nilsson
Journal:  Int J Cancer       Date:  1976-05-15       Impact factor: 7.396

7.  Interleukin-1 beta and interleukin-1 alpha stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells.

Authors:  T Leizer; B J Clarris; P E Ash; J van Damme; J Saklatvala; J A Hamilton
Journal:  Arthritis Rheum       Date:  1987-05

8.  Differential effects of glucocorticosteroids on the functions of subpopulations of helper T lymphocytes.

Authors:  L M Bradley; R I Mishell
Journal:  Eur J Immunol       Date:  1982-01       Impact factor: 5.532

9.  A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

Authors:  F Hirata; E Schiffmann; K Venkatasubramanian; D Salomon; J Axelrod
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

10.  Prevention of the in vitro myelosuppressive effects of glucocorticosteroids by interleukin 1 (IL 1).

Authors:  R I Mishell; D A Lee; K H Grabstein; L B Lachman
Journal:  J Immunol       Date:  1982-04       Impact factor: 5.422
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  100 in total

Review 1.  Molecular mechanisms of glucocorticoid action: what is important?

Authors:  R Newton
Journal:  Thorax       Date:  2000-07       Impact factor: 9.139

2.  A role for endogenous glucocorticoids in wound repair.

Authors:  Richard Grose; Silke Werner; Daniela Kessler; Jan Tuckermann; Katharina Huggel; Silke Durka; Holger M Reichardt; Sabine Werner
Journal:  EMBO Rep       Date:  2002-05-24       Impact factor: 8.807

3.  Downregulation of JE and KC genes by glucocorticoids does not prevent the G0----G1 transition in BALB/3T3 cells.

Authors:  L E Rameh; M C Armelin
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

4.  Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

Authors:  M Gossen; H Bujard
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

5.  Four decades of glucocorticosteroid immunosuppression.

Authors:  P F Halloran
Journal:  CMAJ       Date:  1992-09-01       Impact factor: 8.262

Review 6.  Should we use dexamethasone in meningitis? The Meningitis Working Party of the British Paediatric Immunology and Infectious Diseases Group.

Authors: 
Journal:  Arch Dis Child       Date:  1992-11       Impact factor: 3.791

7.  Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome.

Authors:  John M Busillo; Kathleen M Azzam; John A Cidlowski
Journal:  J Biol Chem       Date:  2011-09-22       Impact factor: 5.157

8.  IL-1β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease.

Authors:  Shresh Pathak; Elliot Goldofsky; Esther X Vivas; Vincent R Bonagura; Andrea Vambutas
Journal:  J Immunol       Date:  2011-01-03       Impact factor: 5.422

9.  Immune-related edemagenic activity of glutamines and glutamic acid, components of immunomodulatory agents.

Authors:  Z Zídek
Journal:  Agents Actions       Date:  1994-10

10.  The effect of adrenalectomy on interleukin-1 release in vitro and in vivo.

Authors:  M Perretti; C Becherucci; G Scapigliati; L Parente
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739
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