OBJECTIVE: To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity. METHODS: We collected data from 18 patients undergoingcisplatin chemotherapy including serum electrolytes, creatinine, blood urea nitrogen (BUN) and urine potassium, sodium and pH levels before and after the cisplatin chemotherapy. All the patients had cancer and were treated with 40-50 mg/day cisplatin. Renal injury was assessed by measuring serum electrolytes, creatinine, BUN levels and urine potassium, sodium and pH levels. RESULTS: The five cycles of cisplatin based chemotherapy resulted in hypomagnesia (P=0.029), hypocalcaemia (P=0.001*), hypophosphatemia (P=0.003*), hypokalemia (P=0.001*) and increased serum creatinine (P=0.001*) and BUN (P=0.292*) levels. In urine analysis, decrease in potassium (P=0.024*) was found, except potassium there was no significant changes in sodium and urine pH. CONCLUSIONS: The present study demonstrates that, acute nephrotoxicity was observed in patients with different types of cancers undergoingcisplatin based chemotherapy due to electrolyte disturbances, when no corrective measures were initiated.
RCT Entities:
OBJECTIVE: To investigate the relationship between serum electrolyte changes and cisplatin induced nephrotoxicity. METHODS: We collected data from 18 patients undergoing cisplatin chemotherapy including serum electrolytes, creatinine, blood ureanitrogen (BUN) and urine potassium, sodium and pH levels before and after the cisplatin chemotherapy. All the patients had cancer and were treated with 40-50 mg/day cisplatin. Renal injury was assessed by measuring serum electrolytes, creatinine, BUN levels and urine potassium, sodium and pH levels. RESULTS: The five cycles of cisplatin based chemotherapy resulted in hypomagnesia (P=0.029), hypocalcaemia (P=0.001*), hypophosphatemia (P=0.003*), hypokalemia (P=0.001*) and increased serum creatinine (P=0.001*) and BUN (P=0.292*) levels. In urine analysis, decrease in potassium (P=0.024*) was found, except potassium there was no significant changes in sodium and urine pH. CONCLUSIONS: The present study demonstrates that, acute nephrotoxicity was observed in patients with different types of cancers undergoing cisplatin based chemotherapy due to electrolyte disturbances, when no corrective measures were initiated.
Authors: Kameswaran Ravichandran; Qian Wang; Abdullah Ozkok; Alkesh Jani; Howard Li; Zhibin He; Danica Ljubanovic; Mary C Weiser-Evans; Raphael A Nemenoff; Charles L Edelstein Journal: J Mol Med (Berl) Date: 2015-12-01 Impact factor: 4.599
Authors: Mohamed M Abdel-Daim; Abdelrahman Ibrahim Abushouk; Thoria Donia; Saud Alarifi; Saad Alkahtani; Lotfi Aleya; Simona G Bungau Journal: Environ Sci Pollut Res Int Date: 2019-03-25 Impact factor: 4.223
Authors: R Rajakrishnan; R Lekshmi; P B Benil; J Thomas; A H AlFarhan; V Rakesh; S Khalaf Journal: Saudi J Biol Sci Date: 2017-01-08 Impact factor: 4.219