Background/Aim: This study aimed to investigate the effects of the combination of alkalization therapy (an alkaline diet and bicarbonate therapy) and intravenous vitamin C treatment on chemotherapy outcomes in patients with small-cell lung cancer (SCLC) (study registration: UMIN000043056). Patients and Methods: Twelve patients with SCLC in the intervention group (receiving both alkalization therapy and vitamin C treatment together with chemotherapy) were retrospectively compared to 15 patients with SCLC in the control group (receiving chemotherapy only). Results: The mean urine pH of the intervention group was significantly higher than that of the control group (7.32±0.45 vs. 6.44±0.74, respectively; p<0.005). The median overall survival for the intervention group was 44.2 months (95% confidence interval=22.0-not reached), as compared with 17.7 months for the control group (95% confidence intervaI=13.5-not reached; p<0.05). Conclusion: The combination of alkalization therapy and intravenous vitamin C treatment may be associated with favorable outcomes in patients with SCLC receiving chemotherapy. Copyright 2021, International Institute of Anticancer Research.
Background/Aim: This study aimed to investigate the effects of the combination of alkalization therapy (an alkaline diet and bicarbonate therapy) and intravenous vitamin C treatment on chemotherapy outcomes in patients with small-cell lung cancer (SCLC) (study registration: UMIN000043056). Patients and Methods: Twelve patients with SCLC in the intervention group (receiving both alkalization therapy and vitamin C treatment together with chemotherapy) were retrospectively compared to 15 patients with SCLC in the control group (receiving chemotherapy only). Results: The mean urine pH of the intervention group was significantly higher than that of the control group (7.32±0.45 vs. 6.44±0.74, respectively; p<0.005). The median overall survival for the intervention group was 44.2 months (95% confidence interval=22.0-not reached), as compared with 17.7 months for the control group (95% confidence intervaI=13.5-not reached; p<0.05). Conclusion: The combination of alkalization therapy and intravenous vitamin C treatment may be associated with favorable outcomes in patients with SCLC receiving chemotherapy. Copyright 2021, International Institute of Anticancer Research.
Authors: Matthew S Alexander; Justin G Wilkes; Samuel R Schroeder; Garry R Buettner; Brett A Wagner; Juan Du; Katherine Gibson-Corley; Brianne R O'Leary; Douglas R Spitz; John M Buatti; Daniel J Berg; Kellie L Bodeker; Sandy Vollstedt; Heather A Brown; Bryan G Allen; Joseph J Cullen Journal: Cancer Res Date: 2018-09-25 Impact factor: 12.701
Authors: Jihye Yun; Edouard Mullarky; Changyuan Lu; Kaitlyn N Bosch; Adam Kavalier; Keith Rivera; Jatin Roper; Iok In Christine Chio; Eugenia G Giannopoulou; Carlo Rago; Ashlesha Muley; John M Asara; Jihye Paik; Olivier Elemento; Zhengming Chen; Darryl J Pappin; Lukas E Dow; Nickolas Papadopoulos; Steven S Gross; Lewis C Cantley Journal: Science Date: 2015-11-05 Impact factor: 47.728
Authors: Ali Mussa; Ros Akmal Mohd Idris; Naveed Ahmed; Suhana Ahmad; Ahmad Hafiz Murtadha; Tengku Ahmad Damitri Al Astani Tengku Din; Chan Yean Yean; Wan Faiziah Wan Abdul Rahman; Norhafiza Mat Lazim; Vuk Uskoković; Khalid Hajissa; Noor Fatmawati Mokhtar; Rohimah Mohamud; Rosline Hassan Journal: Pharmaceuticals (Basel) Date: 2022-06-03