S Kumar1, V Kumar, O M Prakash. 1. Institute of Pharmaceutical Sciences, Kurukshetra University, Haryana, India.
Abstract
OBJECTIVE: To evaluate antidiabetic and hypolipidemic activities of Kigelia pinnata methanolic flowers extract in streptozotocin (STZ) induced diabetic wistar rat. METHODS: Rats were made diabetic by a single dose of STZ at 60 mg/kg body weight i.p. The blood glucose level was checked before and 72 h after STZ injection to confirm the development of diabetes. The flower extract and glibenclamide were administered orally at the doses of 250 and 500 mg/kg body weight for 21 days. RESULTS: Daily oral treatment with the extract and standard drug for 21 days significantly reduced blood glucose, serum cholesterol and triglycerides levels. High density lipoprotein-cholesterol level was found to be improved (P<0.01) as compared to diabetic control group. CONCLUSIONS: It is concluded that Kigellia pinnata flowers extract have significant antidiabetic and hypolipidemic effect.
OBJECTIVE: To evaluate antidiabetic and hypolipidemic activities of Kigelia pinnata methanolic flowers extract in streptozotocin (STZ) induced diabetic wistar rat. METHODS:Rats were made diabetic by a single dose of STZ at 60 mg/kg body weight i.p. The blood glucose level was checked before and 72 h after STZ injection to confirm the development of diabetes. The flower extract and glibenclamide were administered orally at the doses of 250 and 500 mg/kg body weight for 21 days. RESULTS: Daily oral treatment with the extract and standard drug for 21 days significantly reduced blood glucose, serum cholesterol and triglycerides levels. High density lipoprotein-cholesterol level was found to be improved (P<0.01) as compared to diabetic control group. CONCLUSIONS: It is concluded that Kigellia pinnata flowers extract have significant antidiabetic and hypolipidemic effect.
Authors: Wiwit A W Setyaningsih; Nur Arfian; Akbar S Fitriawan; Ratih Yuniartha; Dwi C R Sari Journal: Evid Based Complement Alternat Med Date: 2021-07-06 Impact factor: 2.629