Literature DB >> 23569700

The (a)-Symptomatic Vertebral Fracture: A Frequently Discovered Entity With Clinical Relevance in Fracture Patients Screened on Osteoporosis.

G de Klerk1, J H Hegeman, P Bronkhorst, J van der Palen, D van der Velde, H J Ten Duis.   

Abstract

OBJECTIVE: Description of the prevalence of vertebral fractures in a fracture and osteoporosis outpatient clinic (FO-Clinic) and evaluation of the value of spinal radiographs by screening on osteoporosis.
DESIGN: Retrospective data collection, description, and analysis.
METHODS: All patients admitted to the FO-Clinic during the period of December 2005 until October 2006 were enrolled in this study. At the FO-Clinic spinal radiographs were obtained and bone mineral density (BMD) was measured by Dual energy X-ray-Absorptiometry (DXA).
RESULTS: During the study period, a total of 176 patients were screened at our FO-Clinic. In 41.5% of these patients, a vertebral fracture was diagnosed. There appeared to be an indication for anti-osteoporotic medication in 95 of the 176 patients. Of these 95 patients, 77% could be identified by spinal radiographs. Moreover, only 36% of all patients with a vertebral fracture did suffer from osteoporosis.
CONCLUSION: The prevalence of vertebral fractures in patients screened at an FO-Clinic is high and spinal radiographs can identify up to 77% of patients in which anti-osteoporotic medication should be considered. However, fracture risk is not only dependent on bone quality but also on bone density. Therefore, the preferred method of screening on osteoporosis is DXA with vertebral fracture assessment and, if necessary, spinal radiographs. If DXA is not available, spinal radiographs might be used as a first step in osteoporosis screening.

Entities:  

Keywords:  bone mineral density; dual energy x-ray absorptiometry; osteoporosis; spinal radiograph; vertebral fracture

Year:  2012        PMID: 23569700      PMCID: PMC3598406          DOI: 10.1177/2151458512449833

Source DB:  PubMed          Journal:  Geriatr Orthop Surg Rehabil        ISSN: 2151-4585


  29 in total

Review 1.  Clinical review: Clinical applications of vertebral fracture assessment by dual-energy x-ray absorptiometry.

Authors:  E Michael Lewiecki; Andrew J Laster
Journal:  J Clin Endocrinol Metab       Date:  2006-08-29       Impact factor: 5.958

2.  Effectiveness of instant vertebral assessment to detect prevalent vertebral fracture.

Authors:  R D Chapurlat; F Duboeuf; H O Marion-Audibert; B Kalpakçioglu; B H Mitlak; P D Delmas
Journal:  Osteoporos Int       Date:  2006-06-07       Impact factor: 4.507

3.  Risk of new clinical fractures within 2 years following a fracture.

Authors:  Svenhjalmar van Helden; Jochen Cals; Fons Kessels; Peter Brink; Geert Jan Dinant; Piet Geusens
Journal:  Osteoporos Int       Date:  2005-12-24       Impact factor: 4.507

Review 4.  Treatment of postmenopausal osteoporosis.

Authors:  R Eastell
Journal:  N Engl J Med       Date:  1998-03-12       Impact factor: 91.245

5.  Reliability and accuracy of vertebral fracture assessment with densitometry compared to radiography in clinical practice.

Authors:  John T Schousboe; C Rowan Debold
Journal:  Osteoporos Int       Date:  2005-09-20       Impact factor: 4.507

Review 6.  Epidemiology and outcomes of osteoporotic fractures.

Authors:  Steven R Cummings; L Joseph Melton
Journal:  Lancet       Date:  2002-05-18       Impact factor: 79.321

7.  Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial.

Authors:  P D Delmas; H K Genant; G G Crans; J L Stock; M Wong; E Siris; J D Adachi
Journal:  Bone       Date:  2003-10       Impact factor: 4.398

8.  Evaluation of vertebral fracture assessment by dual X-ray absorptiometry in a multicenter setting.

Authors:  T Fuerst; C Wu; H K Genant; G von Ingersleben; Y Chen; C Johnston; M J Econs; N Binkley; T J Vokes; G Crans; B H Mitlak
Journal:  Osteoporos Int       Date:  2008-12-13       Impact factor: 4.507

9.  BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures.

Authors:  Katie L Stone; Dana G Seeley; Li-Yung Lui; Jane A Cauley; Kristine Ensrud; Warren S Browner; Michael C Nevitt; Steven R Cummings
Journal:  J Bone Miner Res       Date:  2003-11       Impact factor: 6.741

10.  Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures.

Authors:  D Marshall; O Johnell; H Wedel
Journal:  BMJ       Date:  1996-05-18
View more
  1 in total

Review 1.  The Phenotype of Patients with a Recent Fracture: A Literature Survey of the Fracture Liaison Service.

Authors:  Lisanne Vranken; Caroline E Wyers; Joop P W van den Bergh; Piet P M M Geusens
Journal:  Calcif Tissue Int       Date:  2017-05-24       Impact factor: 4.333

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.