A Skvarca1, M Tomazic, R Blagus, B Krhin, A Janez. 1. Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia. ales.skvarca@kclj.si
Abstract
OBJECTIVE: Pregnancy is characterized by progressive insulin resistance. The present study evaluated whether the adiponectin/leptin ratio is associated with insulin resistance in pregnancy, since this ratio has been shown to be associated with insulin resistance in obesity, type 2 diabetes mellitus, metabolic syndrome and polycystic ovary syndrome. METHODS: In this cross-sectional study, adiponectin and leptin concentrations were measured in pregnant women using enzyme-linked immunosorbent assays. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Mean ± SD age of the participants (n = 74) was 30.76 ± 4.27 years, mean ± SD gestational age was 26.81 ± 3.52 weeks and median body mass index (BMI) before pregnancy was 22.68 kg/m(2) (interquartile range 20.75-26.79 kg/m(2)). There was a significant correlation between the HOMA-IR and leptin concentration, but not between the HOMA-IR and adiponectin concentration. There was a significant inverse correlation between the HOMA-IR and adiponectin/leptin ratio. The adiponectin/leptin ratio was inversely correlated with BMI before pregnancy. CONCLUSION: The adiponection/leptin ratio inversely correlates with HOMA-IR in pregnancy.
OBJECTIVE: Pregnancy is characterized by progressive insulin resistance. The present study evaluated whether the adiponectin/leptin ratio is associated with insulin resistance in pregnancy, since this ratio has been shown to be associated with insulin resistance in obesity, type 2 diabetes mellitus, metabolic syndrome and polycystic ovary syndrome. METHODS: In this cross-sectional study, adiponectin and leptin concentrations were measured in pregnant women using enzyme-linked immunosorbent assays. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). RESULTS: Mean ± SD age of the participants (n = 74) was 30.76 ± 4.27 years, mean ± SD gestational age was 26.81 ± 3.52 weeks and median body mass index (BMI) before pregnancy was 22.68 kg/m(2) (interquartile range 20.75-26.79 kg/m(2)). There was a significant correlation between the HOMA-IR and leptin concentration, but not between the HOMA-IR and adiponectin concentration. There was a significant inverse correlation between the HOMA-IR and adiponectin/leptin ratio. The adiponectin/leptin ratio was inversely correlated with BMI before pregnancy. CONCLUSION: The adiponection/leptin ratio inversely correlates with HOMA-IR in pregnancy.
Authors: Silvia Visentin; Annunziata Lapolla; Ambrogio Pietro Londero; Chiara Cosma; Mariagrazia Dalfrà; Martina Camerin; Diego Faggian; Mario Plebani; Erich Cosmi Journal: Biomed Res Int Date: 2014-06-22 Impact factor: 3.411
Authors: Marhazlina Mohamad; See Ling Loy; Poh Ying Lim; Yu Wang; Kah Leng Soo; Hamid Jan Jan Mohamed Journal: Int J Environ Res Public Health Date: 2018-06-12 Impact factor: 3.390