Literature DB >> 2356115

HELP (high efficiency liquid phase) new oligonucleotide synthesis on soluble polymeric support.

G M Bonora1, C L Scremin, F P Colonna, A Garbesi.   

Abstract

A simple, rapid and high-yielding method for the synthesis of oligonucleotides by the phosphotriesters approach is described. The use of polyethylene glycol (PEG) as soluble polymeric support preserves some convenient features of the solid-phase synthesis with new interesting advantages. Short oligonucleotides in hundred milligrams scale can be obtained from few grams of functionalized PEG.

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Year:  1990        PMID： 2356115      PMCID： PMC330918          DOI： 10.1093/nar/18.11.3155

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  6 in total

1.  Liquid phase synthesis of peptides.

Authors:  E Bayer; M Mutter
Journal:  Nature       Date:  1972-06-30       Impact factor: 49.962

2.  OLIGONUCLEOTIDE SYNTHESIS ON A POLYMER SUPPORT.

Authors:  R L LETSINGER; V MAHADEVAN
Journal:  J Am Chem Soc       Date:  1965-08-05       Impact factor: 15.419

3.  Rapid synthesis of oligodeoxyribonucleotides. IV. Improved solid phase synthesis of oligodeoxyribonucleotides through phosphotriester intermediates.

Authors:  M J Gait; M Singh; R C Sheppard; M D Edge; A R Greene; G R Heathcliffe; T C Atkinson; C R Newton; A F Markham
Journal:  Nucleic Acids Res       Date:  1980-03-11       Impact factor: 16.971

4.  New effective method for the synthesis of oligonucleotides via phosphotriester intermediates.

Authors:  V A Efimov; S V Reverdatto; O G Chakhmakhcheva
Journal:  Nucleic Acids Res       Date:  1982-11-11       Impact factor: 16.971

5.  Solid-phase synthesis of polynucleotides. VIII: A simplified synthesis of oligodeoxyribonucleotides.

Authors:  Z K Tan; S Ikuta; T Huang; A Dugaiczyk; K Itakura
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1983

6.  Hydrogen-bonding effects and 13C-NMR of the DNA double helix.

Authors:  P N Borer; S R LaPlante; N Zanatta; G C Levy
Journal:  Nucleic Acids Res       Date:  1988-03-25       Impact factor: 16.971
  6 in total
  11 in total

1.  Liquid-phase combinatorial synthesis.

Authors:  H Han; M M Wolfe; S Brenner; K D Janda
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

2.  Scaffold-directed and traceless synthesis of tricyclic quinoxalinone imidazoles under microwave irradiation: for SCS-09 special issue-combinatorial approaches to drug discovery.

Authors:  Suman Thummanagoti; Chih-Hau Chen; Zhan-Hui Xu; Chung-Ming Sun
Journal:  Mol Divers       Date:  2010-03-20       Impact factor: 2.943

Review 3.  Bioconjugation of oligonucleotides for treating liver fibrosis.

Authors:  Zhaoyang Ye; Houssam S Hajj Houssein; Ram I Mahato
Journal:  Oligonucleotides       Date:  2007

4.  Large scale, liquid phase synthesis of oligonucleotides by the phosphoramidite approach.

Authors:  G M Bonora; G Biancotto; M Maffini; C L Scremin
Journal:  Nucleic Acids Res       Date:  1993-03-11       Impact factor: 16.971

5.  Scalable One-Pot-Liquid-Phase Oligonucleotide Synthesis for Model Network Hydrogels.

Authors:  Guido Creusen; Cecilia Oluwadunsin Akintayo; Katja Schumann; Andreas Walther
Journal:  J Am Chem Soc       Date:  2020-09-16       Impact factor: 15.419

6.  Solution phase synthesis of short oligoribonucleotides on a precipitative tetrapodal support.

Authors:  Alejandro Gimenez Molina; Amit M Jabgunde; Pasi Virta; Harri Lönnberg
Journal:  Beilstein J Org Chem       Date:  2014-09-29       Impact factor: 2.883

Review 7.  Synthesis of oligonucleotides on a soluble support.

Authors:  Harri Lönnberg
Journal:  Beilstein J Org Chem       Date:  2017-07-12       Impact factor: 2.883

Review 8.  Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries.

Authors:  Ruth Suchsland; Bettina Appel; Sabine Müller
Journal:  Beilstein J Org Chem       Date:  2018-02-13       Impact factor: 2.883

9.  Preparation of a disulfide-linked precipitative soluble support for solution-phase synthesis of trimeric oligodeoxyribonucleotide 3´-(2-chlorophenylphosphate) building blocks.

Authors:  Amit M Jabgunde; Alejandro Gimenez Molina; Pasi Virta; Harri Lönnberg
Journal:  Beilstein J Org Chem       Date:  2015-09-07       Impact factor: 2.883

10.  Acetylated and methylated β-cyclodextrins as viable soluble supports for the synthesis of short 2′-oligodeoxyribo-nucleotides in solution.

Authors:  Alejandro Gimenez Molina; Vyacheslav Kungurtsev; Pasi Virta; Harri Lönnberg
Journal:  Molecules       Date:  2012-10-16       Impact factor: 4.411
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