Literature DB >> 23554231

microRNAs are ligands of Toll-like receptors.

Xi Chen1, Hongwei Liang, Junfeng Zhang, Ke Zen, Chen-Yu Zhang.   

Abstract

It has long been known that microRNAs (miRNAs) can regulate target gene expression at the post-transcriptional level. Recent studies, however, have revealed that miRNAs can also be transported from donor cells to recipient cells, in which these RNAs function in a novel manner as ligands of Toll-like receptors. Here, we review the latest findings on these unconventional miRNAs, with special emphasis on their biological significance.

Entities:  

Keywords:  Toll-like receptor; exosome; ligand; microRNA

Mesh：

Substances：

Year:  2013        PMID： 23554231      PMCID： PMC3683908          DOI： 10.1261/rna.036319.112

Source DB:  PubMed          Journal:  RNA        ISSN： 1355-8382            Impact factor:   4.942


  10 in total

Review 1.  MicroRNAs: genomics, biogenesis, mechanism, and function.

Authors:  David P Bartel
Journal:  Cell       Date:  2004-01-23       Impact factor: 41.582

2.  Secreted microRNAs: a new form of intercellular communication.

Authors:  Xi Chen; Hongwei Liang; Junfeng Zhang; Ke Zen; Chen-Yu Zhang
Journal:  Trends Cell Biol       Date:  2012-01-17       Impact factor: 20.808

Review 3.  Intracellular toll-like receptors.

Authors:  Amanda L Blasius; Bruce Beutler
Journal:  Immunity       Date:  2010-03-26       Impact factor: 31.745

4.  miRNA regulates noncoding RNA: a noncanonical function model.

Authors:  Xi Chen; Hongwei Liang; Chen-Yu Zhang; Ke Zen
Journal:  Trends Biochem Sci       Date:  2012-09-08       Impact factor: 13.807

5.  An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.

Authors:  Sabrina M Lehmann; Christina Krüger; Boyoun Park; Katja Derkow; Karen Rosenberger; Jan Baumgart; Thorsten Trimbuch; Gina Eom; Michael Hinz; David Kaul; Piet Habbel; Roland Kälin; Eleonora Franzoni; Agnieszka Rybak; Duong Nguyen; Rüdiger Veh; Olaf Ninnemann; Oliver Peters; Robert Nitsch; Frank L Heppner; Douglas Golenbock; Eckart Schott; Hidde L Ploegh; F Gregory Wulczyn; Seija Lehnardt
Journal:  Nat Neurosci       Date:  2012-06       Impact factor: 24.884

6.  MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response.

Authors:  Muller Fabbri; Alessio Paone; Federica Calore; Roberta Galli; Eugenio Gaudio; Ramasamy Santhanam; Francesca Lovat; Paolo Fadda; Charlene Mao; Gerard J Nuovo; Nicola Zanesi; Melissa Crawford; Gulcin H Ozer; Dorothee Wernicke; Hansjuerg Alder; Michael A Caligiuri; Patrick Nana-Sinkam; Danilo Perrotti; Carlo M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-02       Impact factor: 11.205

7.  MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling.

Authors:  Chunnian Zhao; GuoQiang Sun; Shengxiu Li; Ming-Fei Lang; Su Yang; Wendong Li; Yanhong Shi
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-19       Impact factor: 11.205

8.  Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.

Authors:  Florian Heil; Hiroaki Hemmi; Hubertus Hochrein; Franziska Ampenberger; Carsten Kirschning; Shizuo Akira; Grayson Lipford; Hermann Wagner; Stefan Bauer
Journal:  Science       Date:  2004-02-19       Impact factor: 47.728

9.  MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.

Authors:  Fanyin Meng; Roger Henson; Hania Wehbe-Janek; Kalpana Ghoshal; Samson T Jacob; Tushar Patel
Journal:  Gastroenterology       Date:  2007-05-21       Impact factor: 22.682

Review 10.  Toll-like receptors.

Authors:  Kiyoshi Takeda; Tsuneyasu Kaisho; Shizuo Akira
Journal:  Annu Rev Immunol       Date:  2001-12-19       Impact factor: 28.527
  10 in total
  45 in total

Review 1.  RNA viruses and microRNAs: challenging discoveries for the 21st century.

Authors:  Gokul Swaminathan; Julio Martin-Garcia; Sonia Navas-Martin
Journal:  Physiol Genomics       Date:  2013-09-17       Impact factor: 3.107

Review 2.  In vivo delivery of miRNAs for cancer therapy: challenges and strategies.

Authors:  Yunching Chen; Dong-Yu Gao; Leaf Huang
Journal:  Adv Drug Deliv Rev       Date:  2014-05-22       Impact factor: 15.470

3.  Human papillomavirus 16 E6 and E7 oncoprotein expression alters microRNA expression in extracellular vesicles.

Authors:  Mallory E Harden; Karl Munger
Journal:  Virology       Date:  2017-05-10       Impact factor: 3.616

Review 4.  Mitochondrial damage-associated molecular patterns and vascular function.

Authors:  Camilla Ferreira Wenceslau; Cameron G McCarthy; Theodora Szasz; Kathryn Spitler; Styliani Goulopoulou; R Clinton Webb
Journal:  Eur Heart J       Date:  2014-02-25       Impact factor: 29.983

5.  Extracellular vesicles and viruses: Are they close relatives?

Authors:  Esther Nolte-'t Hoen; Tom Cremer; Robert C Gallo; Leonid B Margolis
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-18       Impact factor: 11.205

Review 6.  Nucleic Acid Delivery for Endothelial Dysfunction in Cardiovascular Diseases.

Authors:  Dipti Deshpande; David R Janero; Victor Segura-Ibarra; Elvin Blanco; Mansoor M Amiji
Journal:  Methodist Debakey Cardiovasc J       Date:  2016-09

7.  Innate immunity sensors participating in pathophysiology of joint diseases: a brief overview.

Authors:  Jiri Gallo; Milan Raska; Yrjo T Konttinen; Christophe Nich; Stuart B Goodman
Journal:  J Long Term Eff Med Implants       Date:  2014

Review 8.  Noncoding RNAs in vascular disease.

Authors:  Amy Leung; Rama Natarajan
Journal:  Curr Opin Cardiol       Date:  2014-05       Impact factor: 2.161

Review 9.  RNA in extracellular vesicles.

Authors:  Kyoung Mi Kim; Kotb Abdelmohsen; Maja Mustapic; Dimitrios Kapogiannis; Myriam Gorospe
Journal:  Wiley Interdiscip Rev RNA       Date:  2017-01-28       Impact factor: 9.957

10.  Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22.

Authors:  Qinglan Wang; So Yeon Kim; Hiroshi Matsushita; Zhijun Wang; Vijay Pandyarajan; Michitaka Matsuda; Koichiro Ohashi; Takashi Tsuchiya; Yoon Seok Roh; Calvin Kiani; Yutong Zhao; Michael Chan; Suzanne Devkota; Shelly C Lu; Tomoko Hayashi; Dennis A Carson; Ekihiro Seki
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-21       Impact factor: 11.205
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