| Literature DB >> 27432966 |
Esther Nolte-'t Hoen1, Tom Cremer1, Robert C Gallo2, Leonid B Margolis3.
Abstract
Extracellular vesicles (EVs) released by various cells are small phospholipid membrane-enclosed entities that can carry miRNA. They are now central to research in many fields of biology because they seem to constitute a new system of cell-cell communication. Physical and chemical characteristics of many EVs, as well as their biogenesis pathways, resemble those of retroviruses. Moreover, EVs generated by virus-infected cells can incorporate viral proteins and fragments of viral RNA, being thus indistinguishable from defective (noninfectious) retroviruses. EVs, depending on the proteins and genetic material incorporated in them, play a significant role in viral infection, both facilitating and suppressing it. Deciphering the mechanisms of EV-cell interactions may facilitate the design of EVs that inhibit viral infection and can be used as vehicles for targeted drug delivery.Entities:
Keywords: defective viruses; exosomes; extracellular vesicles; infection; viruses
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Year: 2016 PMID： 27432966 PMCID： PMC4995926 DOI： 10.1073/pnas.1605146113
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205