Literature DB >> 1707544

Metabolism and mechanism of action of 5-fluorouracil.

W B Parker1, Y C Cheng.   

Abstract

This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA, thymidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5,10-methylene tetrahydrofolate, FUTP.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 1707544     DOI： 10.1016/0163-7258(90)90056-8

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  120 in total

1.  Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer.

Authors:  Xue-Lin Wang; Feng Ma; Xiong-Zhi Wu
Journal:  Chin J Integr Med       Date:  2011-12-08       Impact factor: 1.978

Review 2.  Viral quasispecies evolution.

Authors:  Esteban Domingo; Julie Sheldon; Celia Perales
Journal:  Microbiol Mol Biol Rev       Date:  2012-06       Impact factor: 11.056

3.  Correlation between expression of orotate phosphoribosyl transferase and 5-fluorouracil sensitivity, as measured by apoptosis index in colorectal cancer tissue.

Authors:  Ken Kawai; Suguru Watabe; Mitsuhiro Matsuda; Kazuhiro Sakamoto; Toshiki Kamano
Journal:  Int J Gastrointest Cancer       Date:  2005

4.  In vitro splicing of pre-messenger RNA with extracts from 5-fluorouridine-treated cells.

Authors:  J R Patton
Journal:  Biochem J       Date:  1994-01-15       Impact factor: 3.857

5.  5-fluorouracil enhances exosome-dependent accumulation of polyadenylated rRNAs.

Authors:  Feng Fang; Jason Hoskins; J Scott Butler
Journal:  Mol Cell Biol       Date:  2004-12       Impact factor: 4.272

6.  Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.

Authors:  P V Sahasrabudhe; R T Pon; W H Gmeiner
Journal:  Nucleic Acids Res       Date:  1995-10-11       Impact factor: 16.971

7.  Proteomic analysis of differentially expressed proteins in 5-fluorouracil-treated human breast cancer MCF-7 cells.

Authors:  J Cai; S Chen; W Zhang; Y Wei; J Lu; J Xing; Y Dong
Journal:  Clin Transl Oncol       Date:  2013-11-12       Impact factor: 3.405

8.  Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Authors:  Laura Mojardín; Javier Botet; Sergio Moreno; Margarita Salas
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

9.  Predictive markers for the response to 5-fluorouracil therapy in cancer cells: Constant-field gel electrophoresis as a tool for prediction of response to 5-fluorouracil-based chemotherapy.

Authors:  E M Saleh; R A El-Awady; N Anis
Journal:  Oncol Lett       Date:  2012-10-11       Impact factor: 2.967

10.  IGF-1 partially restores chemotherapy-induced reductions in neural cell proliferation in adult C57BL/6 mice.

Authors:  Michelle C Janelsins; Joseph A Roscoe; Michel J Berg; Bryan D Thompson; Mark J Gallagher; Gary R Morrow; Charles E Heckler; Pascal Jean-Pierre; Lisa A Opanashuk; Robert A Gross
Journal:  Cancer Invest       Date:  2010-06       Impact factor: 2.176
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.