Literature DB >> 23532410

Cyanobacteria: potential candidates for drug discovery.

Rakhi Bajpai Dixit1, M R Suseela.   

Abstract

Cyanobacteria are a rich source of vast array of bioactive molecules including toxins with wide pharmaceutical importance. They show varied bioactivities like antitumor, antiviral, antibacterial, antifungal, antimalarial, antimycotics, antiproliferative, cytotoxicity, immunosuppressive agents and multi-drug resistance reversers. A number of techniques are now developed and standardized for the extraction, isolation, detection and purification of cyanobacterial bioactive molecules. Some of the compounds are showing interesting results and have successfully reached to phase II and phase III of clinical trials. These compounds also serve as lead compounds for the development of synthetic analogues with improved bioactivity. Cyanobacterial bioactive molecules hold a bright and promising future in scientific research and great opportunity for drug discovery. This review mainly focuses on anticancerous, antiviral and antibacterial compounds from cyanobacteria; their clinical status; extraction and detection techniques.

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Year:  2013        PMID: 23532410     DOI: 10.1007/s10482-013-9898-0

Source DB:  PubMed          Journal:  Antonie Van Leeuwenhoek        ISSN: 0003-6072            Impact factor:   2.271


  18 in total

Review 1.  Cyanobacterial secondary metabolites towards improved commercial significance through multiomics approaches.

Authors:  Shaloo Verma; Shobit Thapa; Nahid Siddiqui; Hillol Chakdar
Journal:  World J Microbiol Biotechnol       Date:  2022-04-29       Impact factor: 3.312

Review 2.  Cytochrome P450s in algae: Bioactive natural product biosynthesis and light-driven bioproduction.

Authors:  Shanmin Zheng; Jiawei Guo; Fangyuan Cheng; Zhengquan Gao; Lei Du; Chunxiao Meng; Shengying Li; Xingwang Zhang
Journal:  Acta Pharm Sin B       Date:  2022-01-24       Impact factor: 14.903

3.  Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice.

Authors:  Neil C Lax; Kh Tanvir Ahmed; Christopher M Ignatz; Carmenza Spadafora; Benedict J Kolber; Kevin J Tidgewell
Journal:  Pharm Biol       Date:  2016-05-14       Impact factor: 3.503

4.  Combined LC-MS/MS and Molecular Networking Approach Reveals New Cyanotoxins from the 2014 Cyanobacterial Bloom in Green Lake, Seattle.

Authors:  Roberta Teta; Gerardo Della Sala; Evgenia Glukhov; Lena Gerwick; William H Gerwick; Alfonso Mangoni; Valeria Costantino
Journal:  Environ Sci Technol       Date:  2015-11-24       Impact factor: 9.028

Review 5.  Cyanobacteria-From the Oceans to the Potential Biotechnological and Biomedical Applications.

Authors:  Shaden A M Khalifa; Eslam S Shedid; Essa M Saied; Amir Reza Jassbi; Fatemeh H Jamebozorgi; Mostafa E Rateb; Ming Du; Mohamed M Abdel-Daim; Guo-Yin Kai; Montaser A M Al-Hammady; Jianbo Xiao; Zhiming Guo; Hesham R El-Seedi
Journal:  Mar Drugs       Date:  2021-04-24       Impact factor: 5.118

Review 6.  Structure and Effects of Cyanobacterial Lipopolysaccharides.

Authors:  Prasannavenkatesh Durai; Maria Batool; Sangdun Choi
Journal:  Mar Drugs       Date:  2015-07-07       Impact factor: 5.118

Review 7.  Cyanobacteria and cyanotoxins: from impacts on aquatic ecosystems and human health to anticarcinogenic effects.

Authors:  Giliane Zanchett; Eduardo C Oliveira-Filho
Journal:  Toxins (Basel)       Date:  2013-10-23       Impact factor: 4.546

8.  Supercritical Carbon Dioxide and Microwave-Assisted Extraction of Functional Lipophilic Compounds from Arthrospira platensis.

Authors:  Diego A Esquivel-Hernández; Víctor H López; José Rodríguez-Rodríguez; Gibrán S Alemán-Nava; Sara P Cuéllar-Bermúdez; Magdalena Rostro-Alanis; Roberto Parra-Saldívar
Journal:  Int J Mol Sci       Date:  2016-05-05       Impact factor: 5.923

Review 9.  Indole Alkaloids of the Stigonematales (Cyanophyta): Chemical Diversity, Biosynthesis and Biological Activity.

Authors:  Katherine Walton; John P Berry
Journal:  Mar Drugs       Date:  2016-04-06       Impact factor: 5.118

10.  Cyanobacteria from terrestrial and marine sources contain apoptogens able to overcome chemoresistance in acute myeloid leukemia cells.

Authors:  Liwei Liu; Lars Herfindal; Jouni Jokela; Tania Keiko Shishido; Matti Wahlsten; Stein Ove Døskeland; Kaarina Sivonen
Journal:  Mar Drugs       Date:  2014-04-03       Impact factor: 5.118

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