OBJECTIVES: There is a paucity of information on environmental risk factors for prostate cancer. We conducted a case-control study in Montreal to estimate associations with exposure to ground-level nitrogen dioxide (NO2), a marker for traffic-related air pollution. METHODS: Cases were 803 men with incident prostate cancer, ≤75 years of age, and diagnosed across all French hospitals in Montreal. Concurrently, 969 controls were drawn from electoral lists of French-speaking individuals residing in the same electoral districts as the cases and frequency-matched by age. Concentrations of NO2 were measured across Montreal in 2005-2006. We developed a land use regression model to predict concentrations of NO2 across Montreal for 2006. These estimates were back-extrapolated to 1996. Estimates were linked to residential addresses at the time of diagnosis or interview. Unconditional logistic regression was used, adjusting for potential confounding variables. RESULTS: For each increase of 5 parts per billion of NO2, as estimated from the original land use regression model in 2006, the OR5ppb adjusted for personal factors was 1.44 (95% CI 1.21 to 1.73). Adding in contextual factors attenuated the OR5ppb to 1.27 (95% CI 1.03 to 1.58). One method for back-extrapolating concentrations of NO2 to 1996 (about 10 years before the index date) gave the following OR5ppb: 1.41 (95% CI 1.24 to 1.62) when personal factors were included, and 1.30 (95% CI 1.11 to 1.52) when contextual factors were added. CONCLUSIONS: Exposure to ambient concentrations of NO2 at the current address was associated with an increased risk of prostate cancer. This novel finding requires replication.
OBJECTIVES: There is a paucity of information on environmental risk factors for prostate cancer. We conducted a case-control study in Montreal to estimate associations with exposure to ground-level nitrogen dioxide (NO2), a marker for traffic-related air pollution. METHODS: Cases were 803 men with incident prostate cancer, ≤75 years of age, and diagnosed across all French hospitals in Montreal. Concurrently, 969 controls were drawn from electoral lists of French-speaking individuals residing in the same electoral districts as the cases and frequency-matched by age. Concentrations of NO2 were measured across Montreal in 2005-2006. We developed a land use regression model to predict concentrations of NO2 across Montreal for 2006. These estimates were back-extrapolated to 1996. Estimates were linked to residential addresses at the time of diagnosis or interview. Unconditional logistic regression was used, adjusting for potential confounding variables. RESULTS: For each increase of 5 parts per billion of NO2, as estimated from the original land use regression model in 2006, the OR5ppb adjusted for personal factors was 1.44 (95% CI 1.21 to 1.73). Adding in contextual factors attenuated the OR5ppb to 1.27 (95% CI 1.03 to 1.58). One method for back-extrapolating concentrations of NO2 to 1996 (about 10 years before the index date) gave the following OR5ppb: 1.41 (95% CI 1.24 to 1.62) when personal factors were included, and 1.30 (95% CI 1.11 to 1.52) when contextual factors were added. CONCLUSIONS: Exposure to ambient concentrations of NO2 at the current address was associated with an increased risk of prostate cancer. This novel finding requires replication.
Authors: Lauren A Eaves; Hang T Nguyen; Julia E Rager; Kenneth G Sexton; Thomas Howard; Lisa Smeester; Anastasia N Freedman; Kjersti M Aagaard; Cynthia Shope; Barry Lefer; James H Flynn; Mathew H Erickson; Rebecca C Fry; William Vizuete Journal: Environ Sci Technol Date: 2020-10-16 Impact factor: 9.028
Authors: Katharina Boehm; Roger Valdivieso; Malek Meskawi; Alessandro Larcher; Maxine Sun; José Sosa; Audrey Blanc-Lapierre; Deborah Weiss; Markus Graefen; Fred Saad; Marie-Élise Parent; Pierre I Karakiewicz Journal: World J Urol Date: 2015-04-01 Impact factor: 4.226
Authors: Katharina Boehm; Roger Valdivieso; Malek Meskawi; Alessandro Larcher; Jonas Schiffmann; Maxine Sun; Markus Graefen; Fred Saad; Marie-Élise Parent; Pierre I Karakiewicz Journal: World J Urol Date: 2015-06-25 Impact factor: 4.226
Authors: Keith Van Ryswyk; Greg J Evans; Ryan Kulka; Liu Sun; Kelly Sabaliauskas; Mathieu Rouleau; Angelos T Anastasopolos; Lance Wallace; Scott Weichenthal Journal: J Expo Sci Environ Epidemiol Date: 2020-07-16 Impact factor: 5.563
Authors: Audrey Blanc-Lapierre; Andrea Spence; Pierre I Karakiewicz; Armen Aprikian; Fred Saad; Marie-Élise Parent Journal: BMC Public Health Date: 2015-09-18 Impact factor: 3.295