Literature DB >> 23517681

The VNTR in complex disorders: the forgotten polymorphisms? A functional way forward?

K J Brookes1.   

Abstract

In the last few years, research has focused on single nucleotide polymorphisms (SNPs) in the search for underlying genetic aetiology of complex disorders. This has been afforded by the rapid technological advancement to enable the interrogation of hundreds of thousands of SNPs in one assay via microarrays. However SNPs are only one form of genetic variation and in the midst of the Genome-Wide Association Study (GWAS) explosion Variable Number Tandem Repeat (VNTR) polymorphism exploration has seemingly been left behind. This review will argue that VNTR investigations still hold substantial potential for a role in complex disorders via possible functional properties.
Copyright © 2013 Elsevier Inc. All rights reserved.

Mesh：

Year:  2013        PMID： 23517681     DOI： 10.1016/j.ygeno.2013.03.003

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  22 in total

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Journal:  J Appl Genet       Date:  2016-07-22       Impact factor: 3.240

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6.  Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene.

Authors:  Yuriko Katsumata; David W Fardo; Adam D Bachstetter; Sergey C Artiushin; Wang-Xia Wang; Angela Wei; Lena J Brzezinski; Bela G Nelson; Qingwei Huang; Erin L Abner; Sonya Anderson; Indumati Patel; Benjamin C Shaw; Douglas A Price; Dana M Niedowicz; Donna W Wilcock; Gregory A Jicha; Janna H Neltner; Linda J Van Eldik; Steven Estus; Peter T Nelson
Journal:  J Neuropathol Exp Neurol       Date:  2020-01-01       Impact factor: 3.685

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Review 8.  The association of insertions/deletions (INDELs) and variable number tandem repeats (VNTRs) with obesity and its related traits and complications.

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Journal:  PLoS One       Date:  2017-05-15       Impact factor: 3.240

10.  Differences of Variable Number Tandem Repeats in XRCC5 Promoter Are Associated with Increased or Decreased Risk of Breast Cancer in BRCA Gene Mutation Carriers.

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Journal:  Front Oncol       Date:  2016-04-13       Impact factor: 6.244
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