Literature DB >> 23515076

From optogenetic technologies to neuromodulation therapies.

Justin C Williams1, Timothy Denison.   

Abstract

Optogenetics field of optogenetics has provided new insight into neuronal communication and complex brain function. Now, scientists eagerly anticipate clinical application of this technology, with the hope that it will help improve treatments for various neurological disorders. However, the translational hurdles are high. In this Perspective, we highlight the technical, practical, and regulatory hurdles that lie ahead along the path towards making optogenetic neuromodulation therapies a reality in the clinic.

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Year:  2013        PMID： 23515076     DOI： 10.1126/scitranslmed.3003100

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  30 in total

1.  An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques.

Authors:  Xin Gong; Diego Mendoza-Halliday; Jonathan T Ting; Tobias Kaiser; Xuyun Sun; André M Bastos; Ralf D Wimmer; Baolin Guo; Qian Chen; Yang Zhou; Maxwell Pruner; Carolyn W-H Wu; Demian Park; Karl Deisseroth; Boaz Barak; Edward S Boyden; Earl K Miller; Michael M Halassa; Zhanyan Fu; Guoqiang Bi; Robert Desimone; Guoping Feng
Journal:  Neuron       Date:  2020-04-29       Impact factor: 17.173

2.  A Materials Roadmap to Functional Neural Interface Design.

Authors:  Steven M Wellman; James R Eles; Kip A Ludwig; John P Seymour; Nicholas J Michelson; William E McFadden; Alberto L Vazquez; Takashi D Y Kozai
Journal:  Adv Funct Mater       Date:  2017-07-19       Impact factor: 18.808

3.  Casting light on pain.

Authors:  Liam E Browne; Clifford J Woolf
Journal:  Nat Biotechnol       Date:  2014-03       Impact factor: 54.908

4.  Increasing the expression level of ChR2 enhances the optogenetic excitability of cochlear neurons.

Authors:  Xiankai Meng; Swetha Murali; Yen-Fu Cheng; Jingrong Lu; Ariel E Hight; Vivek V Kanumuri; M Christian Brown; Jeffrey R Holt; Daniel J Lee; Albert S B Edge
Journal:  J Neurophysiol       Date:  2019-09-18       Impact factor: 2.714

5.  Spotlight on movement disorders: What optogenetics has to offer.

Authors:  Mark A Rossi; Nicole Calakos; Henry H Yin
Journal:  Mov Disord       Date:  2015-03-17       Impact factor: 10.338

6.  Engineered Axonal Tracts as "Living Electrodes" for Synaptic-Based Modulation of Neural Circuitry.

Authors:  Mijail D Serruya; James P Harris; Dayo O Adewole; Laura A Struzyna; Justin C Burrell; Ashley Nemes; Dmitriy Petrov; Reuben H Kraft; H Isaac Chen; John A Wolf; D Kacy Cullen
Journal:  Adv Funct Mater       Date:  2017-09-04       Impact factor: 18.808

7.  Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice.

Authors:  Kate L Montgomery; Alexander J Yeh; John S Ho; Vivien Tsao; Shrivats Mohan Iyer; Logan Grosenick; Emily A Ferenczi; Yuji Tanabe; Karl Deisseroth; Scott L Delp; Ada S Y Poon
Journal:  Nat Methods       Date:  2015-08-17       Impact factor: 28.547

Review 8.  Nonhuman Primate Optogenetics: Recent Advances and Future Directions.

Authors:  Adriana Galvan; William R Stauffer; Leah Acker; Yasmine El-Shamayleh; Ken-Ichi Inoue; Shay Ohayon; Michael C Schmid
Journal:  J Neurosci       Date:  2017-11-08       Impact factor: 6.167

9.  Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue.

Authors:  Roarke Horstmeyer; Haowen Ruan; Changhuei Yang
Journal:  Nat Photonics       Date:  2015-08-27       Impact factor: 38.771

10.  Neuroscience. Optogenetic regeneration.

Authors:  Shrivats M Iyer; Scott L Delp
Journal:  Science       Date:  2014-04-04       Impact factor: 47.728
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