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Literature DB >> 27293480

Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue.

Roarke Horstmeyer¹, Haowen Ruan¹, Changhuei Yang¹.

Abstract

In the field of biomedical optics, optical scattering has traditionally limited the range of imaging within tissue to a depth of one millimetre. A recently developed class of wavefront-shaping techniques now aims to overcome this limit and achieve diffraction-limited control of light beyond one centimetre. By manipulating the spatial profile of an optical field before it enters a scattering medium, it is possible to create a micrometre-scale focal spot deep within tissue. To successfully operate in vivo, these wavefront-shaping techniques typically require feedback from within the biological sample. This Review summarizes recently developed 'guidestar' mechanisms that provide feedback for intra-tissue focusing. Potential applications of guidestar-assisted focusing include optogenetic control over neurons, targeted photodynamic therapy and deep tissue imaging.

Entities: Chemical Disease Gene Species

Year: 2015 PMID： 27293480 PMCID： PMC4900467 DOI： 10.1038/nphoton.2015.140

Source DB: PubMed Journal: Nat Photonics ISSN： 1749-4885 Impact factor: 38.771

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