OBJECTIVE: The effects of type 2 resistant starch from high-amylose maize (HAM-RS2) in rodents fed with low-fat diets were demonstrated in previous studies. Fish oil is also reported to reduce body fat. In the current study, the effects of high fat and fish oil on HAM-RS2 feeding in rats were investigated. DESIGN AND METHODS: Rats were fed 0 or 27% (weight) HAM-RS2 with low (15% energy) or high fat (42% energy) diets that included 0 or 10% (energy) tuna oil to test the effect of HAM-RS2 in diet-induced obesity and effects of tuna oil. Data were analyzed as 2 × 2 × 2 factorial. RESULTS: Rats fed HAM-RS2 had decreased cecal contents pH, increased cecal and cecal contents weight, increased cecal contents acetate, propionate, and butyrate, increased GLP-1 and PYY, and decreased abdominal fat. However, high fat partially attenuated effects of HAM-RS2, but increased GLP-1 active. Dietary tuna oil had limited effects at concentration used. CONCLUSIONS: Results demonstrated that a high fat diet partially attenuates the response to HAM-RS2. The mechanism may center on reduced levels of cecal contents propionate and butyrate and reduced serum PYY. This study demonstrated that with consumption of high fat, HAM-RS2 produces fermentation but results in partial attenuation of effects.
OBJECTIVE: The effects of type 2 resistant starch from high-amylosemaize (HAM-RS2) in rodents fed with low-fat diets were demonstrated in previous studies. Fish oil is also reported to reduce body fat. In the current study, the effects of high fat and fish oil on HAM-RS2 feeding in rats were investigated. DESIGN AND METHODS: Rats were fed 0 or 27% (weight) HAM-RS2 with low (15% energy) or high fat (42% energy) diets that included 0 or 10% (energy) tunaoil to test the effect of HAM-RS2 in diet-induced obesity and effects of tunaoil. Data were analyzed as 2 × 2 × 2 factorial. RESULTS:Rats fed HAM-RS2 had decreased cecal contents pH, increased cecal and cecal contents weight, increased cecal contents acetate, propionate, and butyrate, increased GLP-1 and PYY, and decreased abdominal fat. However, high fat partially attenuated effects of HAM-RS2, but increased GLP-1 active. Dietary tunaoil had limited effects at concentration used. CONCLUSIONS: Results demonstrated that a high fat diet partially attenuates the response to HAM-RS2. The mechanism may center on reduced levels of cecal contents propionate and butyrate and reduced serum PYY. This study demonstrated that with consumption of high fat, HAM-RS2 produces fermentation but results in partial attenuation of effects.
Authors: Gregor Reid; Estelle Gaudier; Francisco Guarner; Gary B Huffnagle; Jean M Macklaim; Alicia M Munoz; Margaret Martini; Tamar Ringel-Kulka; Balfour Sartor; Robert Unal; Kristin Verbeke; Jens Walter Journal: Gut Microbes Date: 2010 May-Jun
Authors: Michael J Keenan; Jun Zhou; Kathleen L McCutcheon; Anne M Raggio; H Gale Bateman; Emily Todd; Christina K Jones; Richard T Tulley; Sheri Melton; Roy J Martin; Maren Hegsted Journal: Obesity (Silver Spring) Date: 2006-09 Impact factor: 5.002
Authors: K A Barry; B J Wojcicki; L L Bauer; I S Middelbos; B M Vester Boler; K S Swanson; G C Fahey Journal: J Anim Sci Date: 2011-04-29 Impact factor: 3.159
Authors: June Zhou; Roy J Martin; Richard T Tulley; Anne M Raggio; Kathleen L McCutcheon; Li Shen; Samuel Colby Danna; Sasmita Tripathy; Maren Hegsted; Michael J Keenan Journal: Am J Physiol Endocrinol Metab Date: 2008-09-16 Impact factor: 4.310
Authors: June Zhou; Roy J Martin; Richard T Tulley; Anne M Raggio; Li Shen; Elizabeth Lissy; Kathleen McCutcheon; Michael J Keenan Journal: J Agric Food Chem Date: 2009-10-14 Impact factor: 5.279
Authors: Michael J Keenan; Marlene Janes; Julina Robert; Roy J Martin; Anne M Raggio; Kathleen L McCutcheon; Christine Pelkman; Richard Tulley; M'Famara Goita; Holiday A Durham; June Zhou; Reshani N Senevirathne Journal: Obesity (Silver Spring) Date: 2013-05 Impact factor: 5.002
Authors: Hua V Lin; Andrea Frassetto; Edward J Kowalik; Andrea R Nawrocki; Mofei M Lu; Jennifer R Kosinski; James A Hubert; Daphne Szeto; Xiaorui Yao; Gail Forrest; Donald J Marsh Journal: PLoS One Date: 2012-04-10 Impact factor: 3.240
Authors: Dorothy A Kieffer; Brian D Piccolo; Maria L Marco; Eun Bae Kim; Michael L Goodson; Michael J Keenan; Tamara N Dunn; Knud Erik Bach Knudsen; Sean H Adams; Roy J Martin Journal: J Nutr Date: 2016-10-19 Impact factor: 4.798
Authors: Diana G Carvajal-Aldaz; Justin L Guice; Ryan C Page; Anne M Raggio; Roy J Martin; Claudia Husseneder; Holiday A Durham; James Geaghan; Marlene Janes; Ted Gauthier; Diana Coulon; Michael J Keenan Journal: Mol Nutr Food Res Date: 2016-12-22 Impact factor: 5.914
Authors: M Kristina Hamilton; Charlotte C Ronveaux; Bret M Rust; John W Newman; Melissa Hawley; Daniela Barile; David A Mills; Helen E Raybould Journal: Am J Physiol Gastrointest Liver Physiol Date: 2017-03-09 Impact factor: 4.052
Authors: Felicia Goldsmith; Justin Guice; Ryan Page; David A Welsh; Christopher M Taylor; Eugene E Blanchard; Meng Luo; Anne M Raggio; Rhett W Stout; Diana Carvajal-Aldaz; Amanda Gaither; Christine Pelkman; Jianping Ye; Roy J Martin; James Geaghan; Holiday A Durham; Diana Coulon; Michael J Keenan Journal: Mol Nutr Food Res Date: 2016-08-11 Impact factor: 5.914
Authors: Dorothy A Kieffer; Brian D Piccolo; Maria L Marco; Eun Bae Kim; Michael L Goodson; Michael J Keenan; Tamara N Dunn; Knud Erik Bach Knudsen; Roy J Martin; Sean H Adams Journal: J Nutr Date: 2016-11-02 Impact factor: 4.798
Authors: Michael J Keenan; June Zhou; Maren Hegsted; Christine Pelkman; Holiday A Durham; Diana B Coulon; Roy J Martin Journal: Adv Nutr Date: 2015-03-13 Impact factor: 8.701
Authors: Felicia Goldsmith; Michael J Keenan; Anne M Raggio; Xin Ye; Zheng Hao; Holiday Durham; James Geaghan; Weiping Jia; Roy J Martin; Jianping Ye Journal: PLoS One Date: 2015-05-04 Impact factor: 3.240