Literature DB >> 2351174

In vivo metabolism and kinetics of 99mTc-HMPAO.

G Lucignani1, C Rossetti, P Ferrario, L Zecca, M C Gilardi, F Zito, D Perani, G L Lenzi, F Fazio.   

Abstract

The cerebral distribution of 99mTc-labeled d, l, hexamethyl-propylene-amine-oxime (99mTc-HMPAO) as a function of rCBF and time was examined in rats and in man. The results of this study confirm that 99mTc-HMPAO is distributed in brain in proportion to rCBF. However, the rapid systemic breakdown of the tracer in blood results in considerable difficulties in the assessment of the arterial concentration of the parent compound; incomplete extraction of 99mTc-HMPAO from blood to brain and significant efflux from brain represent further limitations in the use of this tracer for quantification of rCFB. Despite these limitations 99mTc-HMPAO is of potential interest for a qualitative assessment of rCBF in specific clinical conditions.

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Year:  1990        PMID： 2351174     DOI： 10.1007/bf00842776

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  14 in total

1.  Regional blood flow by fractional distribution of indicators.

Authors:  L A SAPIRSTEIN
Journal:  Am J Physiol       Date:  1958-04

2.  The retention of [99mTc]-d,l-HM-PAO in the human brain after intracarotid bolus injection: a kinetic analysis.

Authors:  N A Lassen; A R Andersen; L Friberg; O B Paulson
Journal:  J Cereb Blood Flow Metab       Date:  1988-12       Impact factor: 6.200

3.  Radioiodine-labeled N,N-dimethyl-N'-(2-hydroxy-3-alkyl-5-iodobenzyl)-1,3-propanediamines for brain perfusion imaging.

Authors:  K M Tramposch; H F Kung; M Blau
Journal:  J Med Chem       Date:  1983-02       Impact factor: 7.446

4.  Development of I-123-labeled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain.

Authors:  H S Winchell; R M Baldwin; T H Lin
Journal:  J Nucl Med       Date:  1980-10       Impact factor: 10.057

5.  Initial cerebral HM-PAO distribution compared to LCBF: use of a model which considers cerebral HM-PAO trapping kinetics.

Authors:  J L Lear
Journal:  J Cereb Blood Flow Metab       Date:  1988-12       Impact factor: 6.200

6.  Measurement of local cerebral blood flow with iodo [14C] antipyrine.

Authors:  O Sakurada; C Kennedy; J Jehle; J D Brown; G L Carbin; L Sokoloff
Journal:  Am J Physiol       Date:  1978-01

7.  Metabolic and kinetic considerations in the use of [125I]HIPDM for quantitative measurement of regional cerebral blood flow.

Authors:  G Lucignani; A Nehlig; R Blasberg; C S Patlak; L Anderson; C Fieschi; F Fazio; L Sokoloff
Journal:  J Cereb Blood Flow Metab       Date:  1985-03       Impact factor: 6.200

8.  Regional intracellular pH shift: a proposed new mechanism for radiopharmaceutical uptake in brain and other tissues.

Authors:  H F Kung; M Blau
Journal:  J Nucl Med       Date:  1980-02       Impact factor: 10.057

9.  Technetium-99m d,l-HM-PAO: a new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion.

Authors:  R D Neirinckx; L R Canning; I M Piper; D P Nowotnik; R D Pickett; R A Holmes; W A Volkert; A M Forster; P S Weisner; J A Marriott
Journal:  J Nucl Med       Date:  1987-02       Impact factor: 10.057

10.  Technetium-99m HM-PAO stereoisomers as potential agents for imaging regional cerebral blood flow: human volunteer studies.

Authors:  P F Sharp; F W Smith; H G Gemmell; D Lyall; N T Evans; D Gvozdanovic; J Davidson; D A Tyrrell; R D Pickett; R D Neirinckx
Journal:  J Nucl Med       Date:  1986-02       Impact factor: 10.057
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  4 in total

1.  Motor stimulation response by technetium-99m hexamethylpropylene amine oxime split-dose method and single photon emission tomography.

Authors:  P Pantano; V Di Piero; M Ricci; C Fieschi; L Bozzao; G L Lenzi
Journal:  Eur J Nucl Med       Date:  1992

Review 2.  Quantitative analysis in single photon emission tomography (SPET).

Authors:  K A Blokland; H H Reiber; E K Pauwels
Journal:  Eur J Nucl Med       Date:  1992

3.  In vivo biodistribution of a radiolabeled blood substitute: 99mTc-labeled liposome-encapsulated hemoglobin in an anesthetized rabbit.

Authors:  A S Rudolph; R W Klipper; B Goins; W T Phillips
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

4.  Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using (99m)Tc-HMPAO.

Authors:  Do Won Hwang; Hongyoon Choi; Su Chul Jang; Min Young Yoo; Ji Yong Park; Na Eun Choi; Hyun Jeong Oh; Seunggyun Ha; Yun-Sang Lee; Jae Min Jeong; Yong Song Gho; Dong Soo Lee
Journal:  Sci Rep       Date:  2015-10-26       Impact factor: 4.379
  4 in total

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