Literature DB >> 2351172

Production of carrier-free 66Ga and labeling of antimyosin antibody for positron imaging of acute myocardial infarction.

P Goethals1, M Coene, G Slegers, D Vogelaers, J Everaert, I Lemahieu, F Colardyn, G R Heyndrickx.   

Abstract

A method for labeling monoclonal antimyosin antibodies with 66Ga is described. The radionuclide is a positron emitter (t1/2: 9.4h) produced by means of the 63Cu (4He, n) 66Ga reaction. Purification of the 66Ga from the copper target is described in detail. Monoclonal antimyosin antibodies are labeled with 66Ga at a high yield (99%) by transcomplexation from an acetate buffer with the diethylenetriamine pentaacetic acid (DTPA)-labeled antibody and preliminary evaluated in two dogs for imaging of myocardial necrosis by positron emission tomography.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2351172     DOI： 10.1007/bf00842774

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  9 in total

1.  Investigation of [18F]2-fluoro-2-deoxyglucose for the measure of myocardial glucose metabolism.

Authors:  M E Phelps; E J Hoffman; C Selin; S C Huang; G Robinson; N MacDonald; H Schelbert; D E Kuhl
Journal:  J Nucl Med       Date:  1978-12       Impact factor: 10.057

2.  Labeling of tin-soaked albumin microspheres with 68Ga.

Authors:  D J Hnatowich
Journal:  J Nucl Med       Date:  1976-01       Impact factor: 10.057

3.  Production of gallium-66, a short-lived, positron emitting radionuclide.

Authors:  J Zweit; H Sharma; S Downey
Journal:  Int J Rad Appl Instrum A       Date:  1987

4.  C- 11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. I. Kinetics of C- 11 palmitic acid in normal myocardium.

Authors:  H R Schön; H R Schelbert; G Robinson; A Najafi; S C Huang; H Hansen; J Barrio; D E Kuhl; M E Phelps
Journal:  Am Heart J       Date:  1982-04       Impact factor: 4.749

5.  Specificity of localization of myosin-specific antibody fragments in experimental myocardial infarction. Histologic, histochemical, autoradiographic and scintigraphic studies.

Authors:  B A Khaw; J T Fallon; G A Beller; E Haber
Journal:  Circulation       Date:  1979-12       Impact factor: 29.690

6.  Cyclotron production of carrier-free 66Ga as a positron emitting label of albumin colloids for clinical use.

Authors:  P Goethals; M Coene; G Slegers; P Agon; J Deman; K Schelstraete
Journal:  Eur J Nucl Med       Date:  1988

7.  Effects of coronary artery reperfusion on regional myocardial blood flow and function in conscious baboons.

Authors:  G R Heyndrickx; J Amano; T A Patrick; W T Manders; G G Rogers; C Rosendorff; S F Vatner
Journal:  Circulation       Date:  1985-05       Impact factor: 29.690

8.  Myocardial infarct imaging of antibodies to canine cardiac myosin with indium-111-diethylenetriamine pentaacetic acid.

Authors:  B A Khaw; F T Fallon; H W Strauss; E Haber
Journal:  Science       Date:  1980-07-11       Impact factor: 47.728

9.  Monoclonal antibodies specific for human cardiac myosin: selection, characterization and experimental myocardial infarct imaging.

Authors:  E Hoberg; M Eisenhut; M Hofmann; G Schuler; J Brachmann; I Aidonidis; J Nachtkamp; W Kübler; H A Katus
Journal:  Eur Heart J       Date:  1988-03       Impact factor: 29.983
  9 in total
  1 in total

Review 1.  Radioimmunoimaging with longer-lived positron-emitting radionuclides: potentials and challenges.

Authors:  Tapan K Nayak; Martin W Brechbiel
Journal:  Bioconjug Chem       Date:  2009-05-20       Impact factor: 4.774
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.