Literature DB >> 3261243

Cyclotron production of carrier-free 66Ga as a positron emitting label of albumin colloids for clinical use.

P Goethals1, M Coene, G Slegers, P Agon, J Deman, K Schelstraete.   

Abstract

A method for producing carrier free 66Ga (T1/2:9.4 h; beta +) by 4He bombardment of natural copper targets is presented. 66Ga is formed by means of the 63Cu (4He, n) 66Ga reaction. Production yields are given in the 17.5 to 8 MeV 4He energy range. Chemical purification of 66Ga from the copper target is described. The only radionuclidic impurity found in the final product was 67Ga. Albumin colloids from commercially available kits designed for use with 99mTc could easily be labeled with 66Ga and employed for studies of the lymphatic system by positron emission tomography.

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Year:  1988        PMID： 3261243     DOI： 10.1007/bf00293540

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  3 in total

1.  Labeling of tin-soaked albumin microspheres with 68Ga.

Authors:  D J Hnatowich
Journal:  J Nucl Med       Date:  1976-01       Impact factor: 10.057

2.  Stable labelling of serum albumin microspheres with gallium-68.

Authors:  B Maziere; C Loc'h; M Steinling; D Comar
Journal:  Int J Rad Appl Instrum A       Date:  1986

3.  Gallium-68 labeling of albumin and albumin microspheres.

Authors:  S J Wagner; M J Welch
Journal:  J Nucl Med       Date:  1979-05       Impact factor: 10.057
  3 in total
  3 in total

Review 1.  Unconventional nuclides for radiopharmaceuticals.

Authors:  Jason P Holland; Matthew J Williamson; Jason S Lewis
Journal:  Mol Imaging       Date:  2010-02       Impact factor: 4.488

2.  Production of carrier-free 66Ga and labeling of antimyosin antibody for positron imaging of acute myocardial infarction.

Authors:  P Goethals; M Coene; G Slegers; D Vogelaers; J Everaert; I Lemahieu; F Colardyn; G R Heyndrickx
Journal:  Eur J Nucl Med       Date:  1990

Review 3.  Radioimmunoimaging with longer-lived positron-emitting radionuclides: potentials and challenges.

Authors:  Tapan K Nayak; Martin W Brechbiel
Journal:  Bioconjug Chem       Date:  2009-05-20       Impact factor: 4.774
  3 in total

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