Sandra Amaral1, Rachel Patzer. 1. aDepartment of Pediatrics, The Children's Hospital of Philadelphia bDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA cDepartment of Surgery, Emory Transplant Center, Emory University dDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Abstract
PURPOSE OF REVIEW: Kidney transplantation remains the optimal treatment for children with end-stage renal disease; yet, in the United States, profound differences in access to transplant persist, with black children experiencing significantly reduced access to transplant compared with white children. The reasons for these disparities remain poorly understood. Several recent studies provide new insights into the interplay of socioeconomic status, racial/ethnic disparities and access to pediatric kidney transplantation. RECENT FINDINGS: New evidence suggests that disparities are more pronounced in access to living vs. deceased donors. National allocation policies have mitigated racial differences in pediatric deceased donor kidney transplant (DDKT) access after waitlisting. However, disparities in access to DDKT are stark for minority emerging adults, who lose pediatric priority allocation. Although absence of health insurance poses an important barrier to transplant, even after adjustment for insurance status and neighborhood poverty, disparities persist. Differential access to care and unjust social structures are posited as important modifiable barriers to achieving equity in pediatric transplant access. SUMMARY: Future approaches to overcome disparities in pediatric kidney transplant access must focus on the continuum of the transplant process, including equitable health care access. Public health advocacy efforts to promote national policies that address disparate multilevel socioeconomic factors are essential.
PURPOSE OF REVIEW: Kidney transplantation remains the optimal treatment for children with end-stage renal disease; yet, in the United States, profound differences in access to transplant persist, with black children experiencing significantly reduced access to transplant compared with white children. The reasons for these disparities remain poorly understood. Several recent studies provide new insights into the interplay of socioeconomic status, racial/ethnic disparities and access to pediatric kidney transplantation. RECENT FINDINGS: New evidence suggests that disparities are more pronounced in access to living vs. deceased donors. National allocation policies have mitigated racial differences in pediatric deceased donor kidney transplant (DDKT) access after waitlisting. However, disparities in access to DDKT are stark for minority emerging adults, who lose pediatric priority allocation. Although absence of health insurance poses an important barrier to transplant, even after adjustment for insurance status and neighborhood poverty, disparities persist. Differential access to care and unjust social structures are posited as important modifiable barriers to achieving equity in pediatric transplant access. SUMMARY: Future approaches to overcome disparities in pediatric kidney transplant access must focus on the continuum of the transplant process, including equitable health care access. Public health advocacy efforts to promote national policies that address disparate multilevel socioeconomic factors are essential.
Authors: Lilless M Shilling; Michele L Norman; Kenneth D Chavin; Laura G Hildebrand; Shayna L Lunsford; Margaret S Martin; Jennifer E Milton; Gilbert R Smalls; Prabhakar K Baliga Journal: J Natl Med Assoc Date: 2006-06 Impact factor: 1.798
Authors: Shayna L Lunsford; Kit S Simpson; Kenneth D Chavin; Kerry J Menching; Lucia G Miles; Lilless M Shilling; Gilbert R Smalls; Prabhakar K Baliga Journal: Transplantation Date: 2006-10-15 Impact factor: 4.939
Authors: Douglas B Mogul; Xun Luo; Eric K Chow; Allan B Massie; Tanjala S Purnell; Kathleen B Schwarz; Andrew M Cameron; John F P Bridges; Dorry L Segev Journal: J Pediatr Gastroenterol Nutr Date: 2018-03 Impact factor: 2.839
Authors: Sara A Boynton; Matthew B Matheson; Derek K Ng; Guillermo Hidalgo; Bradley A Warady; Susan L Furth; Meredith A Atkinson Journal: Am J Kidney Dis Date: 2022-01-25 Impact factor: 11.072
Authors: Natalie B Stollon; Christine W Paine; Matthew S Lucas; Lauren D Brumley; Erika S Poole; Tamara Peyton; Anne W Grant; Sophia Jan; Symme Trachtenberg; Miriam Zander; Christopher P Bonafide; Lisa A Schwartz Journal: J Pediatr Hematol Oncol Date: 2015-11 Impact factor: 1.289
Authors: Lucy A Plumb; Manish D Sinha; Anna Casula; Carol D Inward; Stephen D Marks; Fergus J Caskey; Yoav Ben-Shlomo Journal: Clin J Am Soc Nephrol Date: 2021-01-19 Impact factor: 8.237
Authors: Douglas B Mogul; Joy Lee; Tanjala S Purnell; Allan B Massie; Tanveen Ishaque; Dorry L Segev; John F P Bridges Journal: Pediatr Transplant Date: 2019-06-19